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Personale dell'ISS

Carla Fiorentini

Primo ricercatore
+39 06 4990 3006
Viale Regina Elena 299
00161 - Roma (I)
carla.fiorentini@iss.it


Curriculum vitae

Pubblicazioni

  1. Loizzo S, Rimondini-Giorgini R, Travaglione S, Fabbri A, Guidotti M, Ferri A, Campana G, Fiorentini C. CNF1 increases brain energy level, counteracts neuroinflammatory markers and rescues cognitive deficits in a murine model of Alzheimer’s disease. PLoS One 2013;8(5):e65898.
  2. De Filippis B, Fabbri A, Simone D, Canese R, Ricceri L, Malchiodi Albedi F, Laviola G, Fiorentini C. Modulation of RhoGTPases improves the behavioral phenotype and reverses astrocytic deficits in a mouse model of Rett syndrome. Neuropsychopharmacology 2012;37(5):1152-1163.
  3. Fecchi K, Travaglione S, Spadaro F, Quattrini A, Parolini I, Piccaro G, Raggi C, Fabbri A, Felicetti F, Carè A, Fiorentini C, Sargiacomo M. Human melanoma cells express FGFR/Src/Rho signaling that entails an adhesion-independent caveolin-1 membrane association. International journal of cancer 2012;130(6):1273-1283.
  4. Malchiodi Albedi F, Paradisi S, Di Nottia M, Simone D, Travaglione S, Falzano L, Guidotti M, Frank C, Cutarelli A, Fabbri A, Fiorentini C. CNF1 improves astrocytic ability to support neuronal growth and differentiation in vitro. Plos One 2012;7(4):e34115.
  5. Cerri C, Fabbri A, Vannini E, Spolidoro M, Costa M, Maffei L, Fiorentini C, Matteo C. Activation of Rho GTPases triggers structural remodeling and functional plasticity in the adult rat visual cortex. Journal of neuroscience 2011;31(42):15163-15172.
  6. Candela M, Guidotti M, Fabbri A, Brigidi P, Franceschi C, Fiorentini C. Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer. Critical reviews in microbiology 2011;37(1):1-14.
  7. De Viti S, Martino A, Musilli M, Fiorentini C, Diana G. The Rho GTPase activating CNF1 improves associative working memory for object-in-place. Behavioural brain research 2010;212(1):78-83.
  8. Pavone F, Luvisetto S, Marinelli S, Straface E, Fabbri A, Falzano L, Fiorentini C, Malorni V. The Rac GTPase-activating bacterial protein toxin CNF1 induces analgesia up-regulation µ-opioid receptors. Pain 2009;145(1-2):219-229.
  9. Diana G, Valentini G, Travaglione S, Falzano L, Pieri M, Zona C, Meschini S, Fabbri A, Fiorentini C. Enhancement of learning and memory after activation of cerebral Rho GTPases. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2007;104(2):636-641.
  10. Giamboi Miraglia A, Travaglione S, Meschini S, Falzano L, Matarrese P, Quaranta MG, Viora M, Fiorentini C, Fabbri A. Cytotoxic necrotizing factor 1 prevents apoptosis via the AKT/I?B pathway: role of nuclear factor-?B and Bcl-2. Molecular biology of the cell 2007;18(7):2735-2744.
  11. Matarrese P, Falzano L, Fabbri A, Gambardella L, Frank C, Blandine G, Popoff MR, Malorni V, Fiorentini C. Clostridium difficile toxin B causes apoptosis in epithelial cells by thrilling mitochondria: involvement of ATP-sensitive mitochondrial potassium channels. Journal of biological chemistry 2007;282(12):9029-9041.
  12. Giamboi Miraglia A, Travaglione S, Filippini P, Fabbri A, Fiorentini C, Falzano L. A multinucleating Escherichia coli cytotoxin perturbs cell cycle in cultured epithelial cells. Toxicology in vitro 2007;21(2):235-239.
  13. Malorni V, Fiorentini C. Is the Rac GTPase-activating toxin CNF1 a smart hijacker of host cell fate? FASEB journal 2006;20(6):606-609.
  14. Fiorentini C, Malorni V. Exploiting cell death pathways by an E. Coli cytotoxin. Autophagy as a double-edged sword for the host. Autophagy 2006;2(4):310-311.
  15. Falzano L, Filippini P, Travaglione S, Giamboi Miraglia A, Fabbri A, Fiorentini C. Escherichia coli cytotoxic necrotizing factor 1 blocks cell cycle G2/M transition in uroepithelial cells. Infection and immunity 2006;74(7):3765-3772.
  16. Di Biase A, Di Benedetto R, Fiorentini C, Travaglione S, Salvati S, Attorri L, Pietraforte D. Free radical release in C6 glial cells enriched in hexacosanoic acid: implication for X-linked adrenoleukodystrophy pathogenesis. Neurochemistry international 2004;44(3):215-221.
  17. Boyer L, Travaglione S, Falzano L, Gauthier NC, Popoff MR, Lemichez E, Fiorentini C, Fabbri A. Rac GTPase instructs nuclear factor-kB activation by conveying the SCF complex and IkBalfa to the ruffling membranes. Molecular biology of the cell 2004;15(3):1124-1133.
  18. Frank C, Giammarioli AM, Pepponi R, Fiorentini C, Rufini S. Cholesterol pertubing agents inhibit NMDA-dependent calcium influx in rat hippocampal primary culture. FEBS letters 2004;566(1-3):25-29.
  19. Meschini S, Marra M, Calcabrini A, Falzano L, Colone M, De Berardis B, Fiorentini C, Arancia G, Paoletti L. Morphological and functional alterations induced by PM2.5 in human lung ephitelial cells (A549). In: 1. Convegno nazionale sul particolato atmosferico: problematiche e prospettive (PM2004). Abstracts; 12-14 maggio 2004; Milano. 2004.
  20. Falzano L, Filippini P, Travaglione S, Fiorentini C. Epithelial cytokine response in Escherichia coli infection: role of cytotoxic necrotizing factor 1. In: Recent research developments in infection and immunity. Vol. 2 Trivandrum: Transworld Research Network; 2004. p.2-10.
  21. Meschini S, Calcabrini A, Marra M, Falzano L, Colone M, De Berardis B, Paoletti L, Arancia G, Fiorentini C. Morphological and functional alterations induced by fine environmental particulate in cultured lung epithelial cells [abstract]. Toxicology letters 2003;144(Suppl 1):s182.
  22. Cozzolino M, Stagni V, Spinardi L, Campioni N, Fiorentini C, Salvati E, Alemà S, Salvatore AM. p120 Catenin is required for growth factor-dependent cell motility and scattering in epithelial cells. Molecular biology of the cell 2003;14(5):1964-1977.
  23. Fiorentini C, Falzano L, Travaglione S, Fabbri A. Hijacking Rho GTPases by protein toxins and apoptosis: molecular strategies of pathogenic bacteria. Cell death and differentiation 2003;10(2):147-152.
  24. Falzano L, Quaranta MG, Travaglione S, Filippini P, Fabbri A, Viora M, Donelli G, Fiorentini C. Cytotoxic necrotizing factor 1 enhances reactive oxygen species-dependent transcription and secretion of proinflammatory cytokines in human uroepithelial cells. Infection and immunity 2003;71(1):4178-4181.
  25. Travaglione S, Bruni BM, Falzano L, Paoletti L, Fiorentini C. Effects of the new-identified amphibole fluoro-edenite in lung epithelial cells. Toxicology in vitro 2003;17(5-6):547-552.
  26. Malorni V, Quaranta MG, Straface E, Falzano L, Fabbri A, Viora M, Fiorentini C. The Rac-activating toxin cytotoxic necrotizing factor 1 oversees NK cell-mediated activity by regulating the actin/microtubule interplay. Journal of immunology 2003;171(8):4195-4202.
  27. Fabbri A, Falzano L, Travaglione S, Stringaro A, Malorni V, Fais S, Fiorentini C. Rho-activating Escherichia coli cytotoxic necrotizing factor 1: macropinocytosis of apoptotic bodies in human epithelial cells. International journal of medical microbiology 2002;291(6-7):551-554.
  28. Frank C, Giammarioli AM, Falzano L, Fiorentini C, Rufini S. Glutamate-induced calcium increase in myotubes depends on up-regulation of a sodium-dependent trasporter. FEBS letters 2002;527(1-3):269-273.
  29. Fiorentini C, Falzano L, Fabbri A, Stringaro A, Logozzi M, Travaglione S, Contamin S, Arancia G, Malorni V, Fais S. Activation of Rho GTPases by cytotoxic necrotizing factor 1 induces macropinocytosis and scavenging activity in epithelial cells. Molecular biology of the cell 2001;12(7):2061-2073.
  30. Falzano L, Rivabene R, Santini MT, Fabbri A, Fiorentini C. An Escherichia coli cytotoxin increases superoxide anion generation via rac in epithelial cells. Biochemical and biophysical research communications 2001;283(5):1026-1030.
  31. Falzano L, Rivabene R, Santini MT, Fabbri A, Fiorentini C. An Escherichia coli cytotoxin increases superoxide anion generation via rac in epithelial cells. Biochemical and biophysical research communications 2001;283(5):1026-1030.
  32. Raimondi F, Kao JP, Fiorentini C, Fabbri A, Donelli G, Gasparini N, Rubino A, Fasano A. Enterotoxicity and cytotoxicity of vibrio parahaemolyticus thermostable direct hemolysin in in vitro systems. Infection and immunity 2000;68(6):3180-3185.
  33. Fabbri A, Falzano L, Frank C, Donelli G, Matarrese P, Raimondi F, Fasano A, Fiorentini C. Vibrio parahaemolyticus thermostable direct hemolysin modulates cytoskeletal organization and calcium homeostasis in intestinal cultured cells. Infection and immunity 1999;67(3):1139-1148.
  34. Fiorentini C, Falzano L, Barbieri E, Donelli G. Studio in vitro sul meccanismo d'azione di tossine prodotte da microalghe e/o da batteri. In: Funari E, ed. Alcuni studi su problematiche sanitarie per la salvaguardia del mare Adriatico. Prima fase. Roma: Istituto Superiore di Sanità; 1999. (Rapporti ISTISAN 99/34). p.38-48.
  35. Barbieri E, Falzano L, Fiorentini C, Pianetti A, Baffone W, Fabbri A, Matarrese P, Casiere A, Katouli M, Kuhn I, Mollby R, Bruscolini F, Donelli G. Occurence, diversity, and pathogenicity of halophilic Vibrio spp. and non-O1 Vibrio cholerae from estuarine waters along the Italian Adriatic coast. Applied and environmental microbiology 1999;65(6):2748-2753.
  36. Fiorentini C, Gauthier M, Donelli G, Boquet P. Bacterial toxins and Rho GTP-binding protein: what microbes teach us about cell regulation. Cell death and differentiation 1998;5(9):720-728.
  37. Fiorentini C, Fabbri A, Falzano L, Fattorossi A, Matarrese P, Rivabene R, Donelli G. Clostridium difficile toxin B induces apoptosis in intestinal cultured cells. Infection and immunity 1998;66(6):2660-2665.
  38. Malorni V, Fais S, Fiorentini C. Morphological aspects of apoptosis. In: Boraschi D, Bossù P, Cossarizza A, ed. Apoptosis. A laboratory manual of experimental methods L'Aquila: Graphic Press; 1998.
  39. Fiorentini C, Barbieri E, Falzano L, Matarrese P, Baffone W, Pianetti A, Katouli M, Kuhn I, Mollby R, Bruscolini F, Casiere A, Donelli G. Occurrence, diversity and pathogenicity of mesophilic Aeromonas in estuarine waters of the Italian coast of the Adriatic Sea. Journal of applied microbiology 1998;85(3):501-511.
  40. Fiorentini C, Matarrese P, Straface E, Falzano L, Donelli G, Boquet P, Malorni V. Rho-dependent cell spreading activated by E. coli cytotoxic necrotizing factor 1 hinders apoptosis in epithelial cells. Cell death and differentiation 1998;5(11):921-929.
  41. Fiorentini C, Matarrese P, Straface E, Falzano L, Fabbri A, Donelli G, Cossarizza A, Boquet P, Malorni V. Toxin-induced activation of Rho GTP-binding protein increases Bcl-2 expression and influences mitochondrial homeostasis. Experimental cell research 1998;242(1):341-350.
  42. Boquet P, Munro P, Fiorentini C, Just I. Toxins from anaerobic bacteria: specificity and molecular mechanisms of action. Current opinion in microbiology 1998;1(1):66-74.
  43. Fiorentini C, Fabbri A, Flatau G, Donelli G, Matarrese P, Lemichez E, Falzano L, Boquet P. Escherichia coli cytotoxic necrotizing factor 1 (CNF1): a toxin that activates the Rho GTPase. Journal of biological chemistry 1997;272(31):19532-19537.
  44. Fiorentini C, Fabbri A, Matarrese P, Falzano L, Boquet P, Malorni V. Hinderance of apoptosis and phagocytic behaviour induced by Escherichia coli cytotoxic necrotizing factor 1: two related activities in epithelial cells. Biochemical and biophysical research communications 1997;241(2):341-346.
  45. Flatau G, Lemichez E, Gauthier M, Chardin P, Paris S, Fiorentini C, Boquet P. Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine. Nature 1997;387(6634):729-733.

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