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Personale dell'ISS

Roberta Pacifici

Dirigente di ricerca
+39 06 4990 2909
Viale Regina Elena 299
00161 - Roma (I)
roberta.pacifici@iss.it


Curriculum vitae

Direttore di Centro DIDOP - Centro nazionale dipendenze e doping

Pubblicazioni

  1. Fortes C, Mastroeni S, Sperati A, Pacifici R, Zuccaro P, Forastiere F, Agabiti N, Piras G, D'Amicis A, Shah E. Walking four times weekly for at least 15 min is associated with longevity in a Cohort of very elderly people. Maturitas 2013;74(3):246-251.
  2. Gallus S, Lugo A, Colombo P, Pacifici R, La Vecchia C. Smoking prevalence in Italy 2011 and 2012, with a focus on hand-rolled cigarettes. Preventive medicine 2013;56(5):314-318.
  3. Papaseit E, Marchei E, Mortali C, Aznar G, García-Algar O, Farrè M, Pacifici R, Pichini S. Development and validation of a liquid chromatography-tandem mass spectrometry assay for hair analysis of atomoxetine and its metabolites: application in clinical practice. Forensic science international 2012;218(1-3):62-67.
  4. Gallus S, Valentina R, Zuccaro P, Pacifici R, Colombo P, Manzari M, La Vecchia C. Attitudes towards the extension of smoking restrictions to selected outdoor areas in Italy. Tobacco control 2012;21(1):59-62.
  5. Joya X, Friguls B, Ortigosa S, Papaseit E, Martínez S, Manich A, Garcia-Algar O, Pacifici R, Vall O, Pichini S. Determination of maternal-fetal biomarkers of prenatal exposure to ethanol: A review. Journal of pharmaceutical and biomedical analysis 2012;69:209-222.
  6. Marchei E, Papaseit E, García-Algar O, Farrè M, Pacifici R, Pichini S. Determination of atomoxetine and its metabolites in conventional and non-conventional biological matrices by liquid chromatography–tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis 2012;60:26-31.
  7. Gallus S, Tramacere I, Pacifici R, Zuccaro P, Colombo P, Ghislandi S, La Vecchia C. Smoking in Italy 2008–2009: A rise in prevalence related to the economic crisis? [letter]. Preventive medicine 2011;52(2):182-183.
  8. Pellegrini M, Bossù E, Pacifici R, Pichini S. Simple and rapid analysis of methyldibromo glutaronitrile in cosmetic products by gas chromatography mass spectrometry. Journal of pharmaceutical and biomedical analysis 2011;56(5):1112-1116.
  9. Pellegrini M, Marchei E, Pacifici R, Rotolo MC, Pichini S. Advances in the analysis of non-allowed pharmacologically active substances in cosmetic products. Journal of pharmaceutical and biomedical analysis 2011;55(4):842-847.
  10. Marchei E, Farrè M, Pardo R, García-Algar O, Pellegrini M, Pacifici R, Pichini S. Correlation between methylphenidate and ritalinic acid concentrations in oral fluid and plasma. Clinical chemistry 2010;56(4):585-592.
  11. Martín-Santos R, Torrens M, Poudevida S, Langohr K, Cuyàs E, Pacifici R, Farrè M, Pichini S, de la Torre R. 5-HTTLPR polymorphism, mood disorders and MDMA use in a 3-year follow-up study. Addiction biology 2010;15(1):15-22.
  12. Pichini S, Farrè M, Abanades S, Pacifici R, Zuccaro P, Langohr K, de La Torre R. Immunomodulating properties of gamma-hydroxybutyrate (GHB), flunitrazepam and ethanol in 'club drugs' users. Addiction biology 2010;15(3):336-345.
  13. Marchei E, Farrè M, Pardo R, García-Algar O, Pellegrini M, Pacifici R, Pichini S. Usefulness of sweat testing for the detection of methylphenidate after fast- and extended-release drug administration: a pilot study. Therapeutic drug monitoring 2010;32(4):508-511.
  14. Passeri G, Vescovini R, Sansoni P, Galli C, Franceschi C, Passeri M, Italian Multicenter Study on Centenarians (IMUSCE). Calcium metabolism and vitamin D in the extreme longevity. Experimental gerontology 2008;43(2):79-87.
  15. de Sola Llopis S, Miguelez-Pan M, Peña-Casanova J, Poudevida S, Farrè M, Pacifici R, Böhm P, Abanades S, Verdejo Garcia A, Langohr K, Zuccaro P, de La Torre R. Cognitive performance in recreational ecstasy polydrug users: a two-year follow-up study. Journal of psychopharmacology 2008;22(5):498-510.
  16. Marchei E, Joya X, García-Algar O, Vall Combelles O, Pacifici R, Pichini S. Ultrasensitive detection of nicotine and cotinine in teeth by high-performance liquid chromatography/tandem mass spectrometry [letter]. Rapid communications in mass spectrometry 2008;22(16):2609-2612.
  17. Mansi G, Raimondi F, Pichini S, Capasso L, Sarno M, Zuccaro P, Pacifici R, García-Algar O, Romano A, Paludetto R. Neonatal urinary cotinine correlates with behavioral alterations in newborns prenatally exposed to tobacco smoke. Pediatric research 2007;61(2):257-261.
  18. Pacifici R, Zuccaro P, Farrè M, Poudevida S, Abanades S, Pichini S, Langohr K, Segura J, de La Torre R. Combined immunomodulating properties of 3,4-methylenedioxymethamphetamine (MDMA) and cannabis in humans. Addiction 2007;102:931-936.
  19. Mazzone AM, Faggioli P, Giani L, Pacifici R, Pichini S, Rondena M, Zuccaro P. Effects of intravenous iloprost on TGF B1, IL2, IL10 in systemic sclerosis and peripheral arterial disease [abstract]. Annals of the rheumatic diseases 2007;66(Suppl):A14.
  20. Ventura M, Pichini S, Ventura R, Zuccaro P, Pacifici R, de La Torre R. Stability studies of principal illicit drugs in oral fluid: preparation of reference materials for external quality assessment schemes. Therapeutic drug monitoring 2007;29(5):662-665.
  21. Gallus S, Zuccaro P, Colombo P, Apolone G, Pacifici R, Garattini S, La Vecchia C. Effects of new smoking regulations in Italy. Annals of oncology 2006;17(2):346-347.
  22. Gallus S, Pacifici R, Colombo P, Scarpino V, Zuccaro P, Bosetti C, Fernández E, Apolone G, La Vecchia C. Prevalence of smoking and attitude towards smoking regulation in Italy, 2004. European journal of cancer 2006;15(1):77-81.
  23. Marchei E, Pellegrini M, Pacifici R, Palmi I, Lozano J, García-Algar O, Pichini S. Quantification of ? 9-tetrahydrocannabinol and its major metabolites in meconium by gas chromatographic-mass spectrometric assay: assay validation and preliminary results of the "Meconium Project". Therapeutic drug monitoring 2006;28(5):700-706.
  24. Pichini S, Poudevida S, Pujadas M, Menoyo E, Pacifici R, Farrè M, de La Torre R. Assessment of chronic exposure to MDMA in a group of consumers by segmental hair analysis. Therapeutic drug monitoring 2006;28(1):106-109.
  25. Gallus S, Fernández E, Pacifici R, Colombo P, Zuccaro P, Bosetti C, Apolone G, La Vecchia C. Channels of cigarette distribution, price and tobacco consumption in Italy. Preventive medicine 2006;42:132-134.
  26. Pellegrini M, Casà A, Marchei E, Pacifici R, Mayné R, Barbero V, García-Algar O, Pichini S. Development and validation of a gas chromatography-mass spectrometry assay for opiates and cocaine in human teeth. Journal of pharmaceutical and biomedical analysis 2006;40(3):662-668.
  27. Segura M, Farrè M, Pichini S, Peirò AM, Roset PN, Ramirez A, Ortuño J, Pacifici R, Zuccaro P, Segura J, de La Torre R. Contribution of cytochrome P450 2D6 to 3,4-methylenedioxymethamphetamine disposition in humans: use of paroxetine as a metabolic inhibitor probe. Clinical pharmacokinetics 2005;44(6):649-660.
  28. Gallus S, Pacifici R, Colombo P, La Vecchia C, Garattini S, Apolone G, Zuccaro P. Tobacco dependence in the general population in Italy. Annals of oncology 2005;16(5):703-706.
  29. Gallus S, Pacifici R, Colombo P, La Vecchia C, Garattini S, Apolone G. Tobacco dependence in the general population in Italy. Annals of oncology 2005;16(5):703-706.
  30. Pichini S, Abanades S, Farrè M, Pellegrini M, Marchei E, Pacifici R, de La Torre R, Zuccaro P. Quantification of the plant-derived hallucinogen Salvinorin A in conventional and non-conventional biological fluids by gas chromatography/mass spectrometry after Salvia divinorum smoking. Rapid communications in mass spectrometry 2005;19(12):1649-1656.
  31. Pichini S, Marchei E, Pacifici R, Pellegrini M, Lozano J, García-Algar O. Application of a validated high-performance liquid chromatography-mass spectrometry assay to the analysis of m- and p-hydroxybenzoylecgonine in meconium. Journal of chromatography B. Analytical technologies in the biomedical and life sciences 2005;820(1):151-156.
  32. de La Torre R, Farrè M, Navarro M, Pacifici R, Zuccaro P, Pichini S. Clinical pharmacokinetics of amfetamine and related substances. Monitoring in conventional and non-conventional matrices. Clinical pharmacokinetics 2004;43(3):157-185.
  33. Pacifici R, Zuccaro P, Pichini S, Segura M, Ortuño J, Farrè M, Di Carlo S, Bacosi A, Roset PN, Segura J, de La Torre R. Paroxetine inhibits acute effects of 3,4-methylenedioxymethamphetamine on the immune system in humans. Journal of pharmacology and experimental therapeutics 2004;309(1):285-292.
  34. Pacifici R, Zuccaro P, Gallus S, Colombo MP, Garattini S, La Vecchia C. Use of cigarette vending machines by minors in Italy [letter]. International journal of epidemiology 2004;33(2):432.
  35. Laviola G, Rea M, Morle Fletcher S, Di Carlo S, Bacosi A, De Simone R, Bertini M, Pacifici R. Beneficial effects of enriched environment on adolescent rats from stressed pregnancies. European journal of neuroscience 2004;20(6):1655-1664.
  36. Abellan R, Ventura R, Pichini S, Sarda MP, Remacha AF, Pascual JA, Palmi I, Bacosi A, Pacifici R, Zuccaro P, Segura J. Evaluation of immunoassays for the measurement of soluble transferrin receptor as an indirect biomarker of recombinant human erythropoietin misuse in sport. Journal of immunological methods 2004;295(1-2):89-99.
  37. Pichini S, Pacifici R, Pellegrini M, Marchei E, Lozano J, Murillo J, Vall Combelles O, García-Algar O. Development and validation of a high-performance liquid chromatography-mass spectrometry assay for determination of amphetamine, methamphetamine, and methylenedioxy derivatives in meconium. Analytical chemistry 2004;76(7):2124-2132.
  38. Algar OG, Puig C, Vall Combelles O, Pacifici R, Pichini S. Effects of maternal smoking during pregnancy on newborn neurobehavior: neonatal nicotine withdrawal syndrome [letter]. Pediatrics 2004;113(3 Pt 1):623-624.
  39. Pichini S, Pacifici R, Pellegrini M, Marchei E, Pèrez-Alarcon E, Puig C, Vall Combelles O, García-Algar O. Development and validation of a liquid chromatography-mass spectrometry assay for the determination of opiates and cocaine in meconium. Journal of chromatography B. Analytical technologies in the biomedical and life sciences 2003;794(2):281-292.
  40. Fortes C, Farchi S, Forastiere F, Agabiti N, Pacifici R, Zuccaro P, Perucci CA, Ebrahim S. Depressive symptoms lead to impaired cellular immune response. Psychotherapy and psychosomatics 2003;72(5):253-260.
  41. Pacifici R, Fiaschi AI, Micheli L, Centini F, Giorgi G, Zuccaro P, Pichini S, Di Carlo S, Bacosi A, Cerretani D. Immunosuppression and oxidative stress induced by acute and chronic exposure to cocaine in rat. International immunopharmacology 2003;3(4):581-592.
  42. Pacifici R, Zuccaro P, Pichini S, Roset PN, Poudevida S, Farrè M, Segura J, de La Torre R. Modulation of the immune system in cannabis users. JAMA 2003;289(15):1929-1931.
  43. Segura M, Ortuño J, Farrè M, Pacifici R, Pichini S, Joglar J, Segura J, de La Torre R. Quantitative determination of paroxetine and its 4-hidroxy-3-methody metabolite in plasma by high performance liquid chromatography/electrospray ion trap mass spectrometry: application to pharmacokinetic studies. Rapid communications in mass spectrometry 2003;17(13):1455-1461.
  44. García-Algar O, Vall Combelles O, Segura J, Pascual JA, Diaz D, Muñoz L, Zuccaro P, Pacifici R, Pichini S. Nicotine concentrations in deciduous teeth and cumulative exposure tobacco smoke during childhood [letter]. JAMA 2003;290(2):196-197.
  45. Pichini S, Pellegrini M, Pacifici R, Marchei E, Murillo J, Puig C, Vall Combelles O, García-Algar O. Quantification of arecoline (Areca nut alkaloid) in neonatal biological matrices by high-performance liquid chromatography/electrospray quadrupole mass spectrometry. Rapid communications in mass spectrometry 2003;17(17):1958-1964.
  46. Pascual JA, Diaz D, Segura J, García-Algar O, Vall Combelles O, Zuccaro P, Pacifici R, Pichini S. A simple and reliable method for the determination of nicotine and cotinine in teeth by gas chromatography/mass spectrometry. Rapid communications in mass spectrometry 2003;17(24):2853-2855.
  47. Jannuzzi G, Gatti G, Magni P, Spina E, Pacifici R, Zuccaro P, Torta R, Guarneri L, Perucca E. Plasma concentrations of the enantiomers of fluoxetine and norfluoxetine: sources of variability and preliminary observations on relations with clinical response. Therapeutic drug monitoring 2002;24(5):616-627.
  48. Pichini S, Navarro M, Farrè M, Ortuño J, Roset PN, Pacifici R, Zuccaro P, Segura J, de La Torre R. On-site testing of 3,4-Methylenedioxymethamphetamine (Ecstasy) in saliva with drugwipe and drugread: a controlled study in recreational users. Clinical chemistry 2002;48(1):174-176.
  49. Loizzo A, Loizzo S, Lopez L, D'Amore A, Renzi P, Spampinato S, Di Carlo S, Bacosi A, Zuccaro P, Pacifici R. Naloxone prevents cell-mediated immune alterations in adult mice following repeated mild stress in the neonatal period. British journal of pharmacology 2002;135(5):1219-1226.
  50. Adriani W, Macrì S, Pacifici R, Laviola G. Peculiar vulnerability to nicotine oral self-administration in mice during early adolescence. Neuropsychopharmacology 2002;27(2):212-224.
  51. Adriani W, Macrì S, Pacifici R, Laviola G. Restricted daily access to water and voluntary nicotine oral consumption in mice: methodological issues and individual differences. Behavioural brain research 2002;134(1-2):21-30.
  52. Pacifici R, Zuccaro P, Lopez CH, Pichini S, Di Carlo S, Farrè M, Roset PN, Ortuño J, Segura J, de La Torre R. Acute effects of 3,4-methylenedioxymethamphetamine alone and in combination with ethanol on the immune system in humans. Journal of pharmacology and experimental therapeutics 2001;296(1):207-215.
  53. Pacifici R, Zuccaro P, Farrè M, Pichini S, Di Carlo S, Bacosi A, Palmi I, Roset PN, Ortuño J, Segura J, de La Torre R. Cell-mediated immune response in "Ecstasy" consumers. Biochimica clinica 2001;25(2):172.
  54. Pacifici R, Zuccaro P, Farrè M, Pichini S, Di Carlo S, Roset PN, Ortuño J, Pujades A, Bacosi A, Menoyo E, Segura J, de La Torre R. Effects of repeated doses of MDMA ("ECStASY") on cell-mediated immune response in humans. Life sciences 2001;69(24):2931-2941.
  55. Pichini S, Pacifici R, Puig C, García-Algar O, Vall Combelles O, Sunyer J. Foetal exposure to tobacco smoke is very common [letter]. Journal of epidemiology and community health 2001;55(12):936.
  56. Zuccaro P, Pacifici R, Giampaoli S, Vanuzzo D, Di Pucchio A, Martucci L, Modigliani G, Mortali C, Pizzi E. Fumo: il contesto epidemiologico nazionale. Italian heart journal 2001;2(Suppl 1):13-18.
  57. García-Algar O, Puig C, Mendez C, Vall Combelles O, Pacifici R, Pichini S. Neonatal nicotine withdrawal syndrome [letter]. Journal of epidemiology and community health 2001;55(9):687-688.
  58. Pichini S, Basagana X, Pacifici R, García-Algar O, Puig C, Vall Combelles O, Harris J, Zuccaro P, Segura J, Sunyer J. Cord serum cotinine as a biomarker of fetal exposure to cigarette smoke at the end of pregnancy. Environmental health perspectives 2000;108(11):1079-1083.
  59. Palmeri A, Pichini S, Pacifici R, Zuccaro P, Lopez A. Drugs in nails: physiology, pharmacokinetics and forensic toxicology. Clinical pharmacokinetics 2000;38(2):95-110.
  60. Pacifici R, Farrè M, Pichini S, Ortuño J, Roset PN, Zuccaro P, Segura J, de La Torre R. Sweat testing of MDMA with the drugwipe analytical device: a controlled study with two volunteers. Journal of analytical toxicology 2000;25(2):144-146.

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