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Personale dell'ISS

Anna Rita Ciccaglione

Primo ricercatore
+39 06 4990 3233
Viale Regina Elena 299
00161 - Roma (I)
annarita.ciccaglione@iss.it


Curriculum vitae

Pubblicazioni

  1. Bruni R, Taffon S, Equestre M, Chionne P, Madonna E, Rizzo C, Tosti ME, Alfonsi V, Ricotta L, De Medici D, Di Pasquale S, Scavia G, Pavoni E, Losio MN, Romanò L, Zanetti AR, Morea A, Pacenti M, Palù G, Capobianchi MR, Chironna M, Pompa MG, Ciccaglione AR, Italian National Task Force on Hepatitis A. Key role of sequencing to trace hepatitis A viruses circulating in Italy during a large multi-country European foodborne outbreak in 2013. PLoS One 2016;11(2):e0149642.
  2. Adlhoch C, Avellon A, Baylis SA, Ciccaglione AR, Couturier E, de Sousa R, et al, Tosti ME. Hepatitis E virus: assessment of the epidemiological situation in humans in Europe, 2014/15. Journal of clinical virology 2016;82:9-16.
  3. Chionne P, Madonna E, Pisani G, Taffon S, La Rosa G, Candido A, Dettori S, Tritarelli E, Equestre M, Bruni R, Ciccaglione AR. Evaluation of rapid tests for diagnosis of acute hepatitis E. Journal of clinical virology 2016;78:4-8.
  4. La Rosa G, Della Libera S, Brambilla M, Bisaglia C, Pisani G, Ciccaglione AR, Bruni R, Taffon S, Equestre M, Iaconelli M. Hepatitis E virus (genotype 3) in slurry samples from swine farming activities in Italy. Food and environmental virology 2016;Epub 2016 Nov 16:http://dx.doi.org/10.1007/s12560-016-9270-4.
  5. Chaouch H, Taffon S, Villano U, Equestre M, Bruni R, Bel Hadj M, Hannachi N, Aouni M, Letaief A, Ciccaglione AR. Naturally occurring surface antigen variants of Hepatitis B virus in Tunisian patients. Intervirology 2016;59(1):36-47.
  6. Sanarico N, D'Amato S, Bruni R, Rovetto C, Salvi E, Di Zeo P, Chionne P, Madonna E, Pisani G, Costantino A, Equestre M, Tosti ME, Cenci A, Maggiorella MT, Sernicola L, Pontali E, Pansera A, Quattrocchi R, Carbonara S, Signorile F, Surace LA, Federzoni G, Garlassi E, Starnini G, Monarca R, Babudieri S, Rapicetta M, Pompa MG, Caraglia A, Ensoli B, Ciccaglione AR, Buttò S. Correlates of infection and molecular characterization of blood-borne HIV, HCV and HBV infections in HIV-1 infected inmates in Italy: an observational cross-sectional study. Medicine 2016;95(44):e5257.
  7. Severi E, Verhoef L, Thornton L, Guzman-Herrador BR, Sundqvist L, Rimhanen-Finne R, Roque-Alfonso A, Ngui S, Allerberger F, Baumann-Popczyl A, Muller L, Parmakova K, Alfonsi V, Tavoschi L, Vennema H, Fitzgerald M, Myrmel M, Gertler M, Ederth J, Kontio M, Vanbockstael C, Mandal S, Sadkowska-Todys M, Tosti ME, Schimmer B, O' Gorman J, Stene-Johansen K, Wenzel JJ, Jones J, Balogun K, Ciccaglione AR, O' Connor L, Vold L, Takkinen J, Rizzo C. Large and prolonged food-borne multistate heapatitis A outbreak in Europe associated with consumption of frozen berries, 2013 to 2014. Eurosurveillance 2015;20(29):21192.
  8. Costantino A, Spada E, Equestre M, Bruni R, Tritarelli E, Coppola N, Sagnelli C, Sagnelli E, Ciccaglione AR. Naturally occurring mutations associated with resistance to HCV NS5B polymerase and NS3 protease inhibitors in treatment-naïve patients with chronic hepatitis C. Virology journal 2015;12:186.
  9. Béji-Hamza A, Khélifi-Gharbi H, Hassine-Zaafrane M, Della Libera S, Iaconelli M, Muscillo M, Petricca S, Ciccaglione AR, Bruni R, Taffon S, Aouni M, La Rosa G. Hepatitis E virus genotypes 1 and 3 in wastewater samples in Tunisia. Archives of virology 2015;160(1):183–189.
  10. Beji-Hamza A, Taffon S, Mhalla S, Lo Presti A, Equestre M, Chionne P, Madonna E, Cella E, Bruni R, Ciccozzi M, Aouni M, Ciccaglione AR. Migration pattern of hepatitis A virus genotype IA in North-Central Tunisia. Virology journal 2015;12(1):17.
  11. Iaconelli M, Purpari G, Della Libera S, Petricca S, Guercio A, Ciccaglione AR, Bruni R, Taffon S, Equestre M, Fratini M, Muscillo M, La Rosa G. Hepatitis A and E viruses in wastewaters, in river waters, and in bivalve molluscs in Italy. Food and environmental virology 2015;7(4):316-324.
  12. Stroffolini T, Rapicetta M, Chionne P, Esvan R, Madonna E, Lombardo FL, Toccaceli F, Pisani G, Ciccaglione AR, Bortolotti F. Evidence for the presence of autochthonous (locally acquired) cases of acute hepatitis E virus infections in Italy since the 80s. European journal of internal medicine 2015;26(5):348-350.
  13. Taffon S, Kondili LA, Giuseppetti R, Ciccaglione AR, Pulimanti B, Attili AF, Rapicetta M, D'Ugo E. Woodchuck hepatitis virus core gene deletions and proliferative response of peripheral blood mononuclear cells stimulated by an immunodominant epitope. A viral immune escape in Woodchuck model of chronic hepatitis B? Archives of virology 2015;160(4):1065-1073.
  14. Villano U, Lo Presti A, Equestre M, Cella E, Pisani G, Giovanetti M, Bruni R, Tritarelli E, Amicosante M, Grifoni A, Scarcella C, El-Hamad I, Pezzoli MC, Angeletti S, Ciccaglione AR, Ciccozzi M. Molecular epidemiology and phylogenetic analysis of hepatitis B virus in a group of migrants in Italy. BMC infectious diseases 2015;15:287.
  15. Montaño-Remacha C, Ricotta L, Alfonsi V, Bella A, Tosti ME, Ciccaglione AR, Bruni R, Taffon S, Equestre M, Losio MN, Carraro V, Franchini S, Natter B, Augschiller M, Foppa A, Gualanduzzi C, Massimiliani E, Finarelli AC, Borrini BM, Gallo T, Cozza V, Chironna M, Prato R, Rizzo C, Central Task Force on Hepatitis. Hepatitis A outbreak in Italy, 2013: a matched case-control study. Eurosurveillance 2014;19(37):20906.
  16. Bruni R, Marcantonio C, Pulsoni A, Tataseo P, De Angelis F, Spada E, Marcucci F, Panfilio S, Bianco P, Riminucci M, Villano U, Tosti ME, Ciccaglione AR, Mele A. microRNA levels in paraffin-embedded indolent B-cell non-Hodgkin lymphoma tissues from patients chronically infected with hepatitis B or C virus. BMC infectious diseases 2014;14(5 Suppl):S6.
  17. Béji-Hamza A, Hassine-Zaafrane M, Della Libera S, Iaconelli M, Muscillo M, Petricca S, Ciccaglione AR, Bruni R, Taffon S, Equestre M, Khélifi-Gharbi H, Aouni M, La Rosa G. Qualitative and quantitative assessment of hepatitis A virus in wastewaters in Tunisia. Food and environmental virology 2014;6(4):246-252.
  18. Béji-Hamza A, Khélifi-Gharbi H, Hassine-Zaafrane M, Della Libera S, Iaconelli M, Muscillo M, Petricca S, Ciccaglione AR, Bruni R, Taffon S, Aouni M, La Rosa G. Hepatitits E virus genotypes 1 and 3 in wastewater samples in Tunisia. In: 12. National Congress of the Italian Society for Virology (SIV). Abstract book; September 22-24, 2014; Orvieto. 2014.
  19. La Rosa G, Della Libera S, Iaconelli M, Ciccaglione AR, Bruni R, Taffon S, Equestre M, Alfonsi V, Rizzo C, Tosti ME, Chironna M, Romanò L, Zanetti AR, Muscillo M. Surveillance of hepatitis A virus in urban sewages and comparison with cases notified in the course of an outbreak, Italy 2013. BMC infectious diseases 2014;14:419.
  20. Ciccozzi M, Ciccaglione AR, Lo Presti A, Equestre M, Cella E, Ebranati E, Gabanelli E, Villano U, Bruni R, Yalcinkaya T, Tanzi E, Zehender G. Evolutionary dynamics of HBV-D1 genotype epidemic in Turkey. Journal of medical virology 2014;86(1):109-116.
  21. La Rosa G, Fratini M, Muscillo M, Iaconelli M, Taffon S, Equestre M, Chionne P, Madonna E, Pisani G, Bruni R, Ciccaglione AR. Molecular characterisation of human hepatitis E virus from Italy: comparative analysis of five reverse transcription-PCR assays. Virology journal 2014;11:72.
  22. Rizzo C, Alfonsi V, Bruni R, Busani L, Ciccaglione AR, De Medici D, Di Pasquale S, Equestre M, Escher M, Montaño-Remacha MDC, Scavia G, Taffon S, Carraro V, Franchini S, Natter B, Augschiller M, Tosti ME, Central Task Force on Hepatitis A. Ongoing outbreak of hepatitis A in Italy: preliminary report as of 31 May 2013. Eurosurveillance 2013;18(27):20518.
  23. Parlato S, Bruni R, Fragapane P, Salerno D, Marcantonio C, Borghi P, Tataseo P, Ciccaglione AR, Presutti C, Romagnoli G, Bozzoni I, Belardelli F, Gabriele L. IFN-a regulates Blimp-1 expression via miR-23a and miR-125b in both monocytes-derived DC and pDC. PLoS One 2013;8(8):e72833.
  24. Giuliani A, Bruni R, Ciccozzi M, Lo Presti A, Equestre M, Marcantonio C, Ciccaglione AR. Amino-acid correlated mutations inside a single protein system: a new method for the identification of main coherent directions of evolutive changes. Phylogenetics & evolutionary biology 2013;1(2):111.
  25. Guadagnino V, Stroffolini T, Caroleo B, Menniti Ippolito F, Rapicetta M, Ciccaglione AR, Chionne P, Madonna E, Costantino A, De Sarro G, Focà A, Lentini M, Staltari O, Sersale's Study Group. Hepatitis C virus infection in an endemic area of Southern Italy 14 years later: evidence for a vanishing infection. Digestive and liver disease 2013;45(5):403-407.
  26. Candido A, Taffon S, Chionne P, Pisani G, Madonna E, Dettori S, Hamza A, Valdarchi C, Bruni R, Ciccaglione AR. Diagnosis of HEV infection by serological and real-time PCR assays: a study on acute non-A-C hepatitis collected from 2004 to 2010 in Italy. BMC research notes 2012;5(1):297.
  27. Ciccozzi M, Equestre M, Costantino A, Marascio N, Quirino A, Lo Presti A, Cella E, Bruni R, Liberto MC, Focà A, Pisani G, Zehender G, Ciccaglione AR. Hepatitis C virus genotype 4d in southern Italy: reconstruction of its origin and spread by a phylodynamic analysis. Journal of medical virology 2012;84(10):1613-1619.
  28. Greco E, Quintiliani G, Santucci MB, Serafino A, Ciccaglione AR, Marcantonio C, Papi M, Maulucci G, Delogu G, Martino A, Goletti D, Sarmati L, Andreoni M, Altieri A, Alma M, Caccamo N, Di Liberto D, De Spirito M, Savage ND, Nisini R, Dieli F, Ottenhoff TH, Fraziano M. Janus-faced liposomes enhance antimicrobial innate immune response in Mycobacterium tuberculosis infection. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2012;109(21):E1360-E1368.
  29. Bruni R, Marcantonio C, Tritarelli E, Tataseo P, Stellacci E, Costantino A, Villano U, Battistini A, Ciccaglione AR. An integrated approach identifies IFN-regulated microRNAs and targeted mRNAs modulated by different HCV replicon clones . BMC genomics 2011;12(1):485.
  30. Ciccozzi M, Ciccaglione AR, Lo Presti A, Yalcinkaya T, Taskan ZP, Equestre M, Costantino A, Bruni R, Ebranati E, Salemi M, Gray R, Rezza G, Galli M, Zehender G. Reconstruction of the evolutionary dynamics of the hepatitits C virus 1b epidemic in Turkey. Infection, genetics and evolution 2011;11(5):863-868.
  31. Bruni R, Prosperi M, Marcantonio C, Amadori A, Villano U, Tritarelli E, Lo Presti A, Ciccozzi M, Ciccaglione AR. A computational approach to identify point mutations associated with occult hepatitis B: significant mutations affect coding regions but not regulative elements of HBV. Virology journal 2011;8(1):394.
  32. Ciccozzi M, Lo Presti A, Cenci A, Staltari O, Buttò S, Equestre M, Ciccaglione AR, Caroleo B, Rezza G, Guadagnino V. May phylogenetic analysis support epidemiological investigation in identifying the source of HIV infection? [letter]. AIDS research and human retroviruses 2010;26:
  33. Ciccaglione AR, Miceli M, Pisani G, Bruni R, Iudicone P, Costantino A, Equestre M, Tritarelli E, Marcantonio C, Tataseo P, Marazzi MC, Ceffa S, Paturzo G, Doro Altan A, Magnano San Lio M, Mancinelli S, Ciccozzi M, Lo Presti A, Rezza G, Palombi L. Improving HIV-2 detection by a combination of serological and nucleic acid amplification test assays. Journal of clinical microbiology 2010;48(8):2902-2908.
  34. Bruni R, Costantino A, Tritarelli E, Marcantonio C, Ciccozzi M, Rapicetta M, El Sawaf G, Giuliani A, Ciccaglione AR. A computational approach identifies two regions of hepatitis C virus E1 protein as interacting domains involved in viral fusion process. BMC structural biology 2009;9:48.
  35. Mariotti S, Sargentini V, Marcantonio C, Todero E, Teloni R, Gagliardi MC, Ciccaglione AR, Nisini R. T-cell-mediated and antigen-dependent differentiation of human monocyte into different dendritic cell subsets: a feedback control of Th1/Th2 responses. FASEB journal 2008;22(9):3370-3379.
  36. Ciccaglione AR, Marcantonio C, Tritarelli E, Tataseo P, Ferraris A, Bruni R, Dallapiccola B, Gerosolimo G, Costantino A, Rapicetta M. Microarray analysis identifies a common set of cellular genes modulated by different HCV replicon clones. BMC genomics 2008;9:309.
  37. Ciccaglione AR, Stellacci E, Marcantonio C, Muto V, Equestre M, Marsili G, Rapicetta M, Battistini A. Repression of interferon regulatory factor-1 by hepatitis C virus core protein results in inhibition of antiviral and immunomodulatory genes. Journal of virology 2007;81(1):202-214.
  38. Ciccaglione AR, Marcantonio C, Tritarelli E, Equestre M, Vendittelli F, Costantino A, Geraci A, Rapicetta M. Activation of the ER stress gene gadd153 by hepatitits C virus sensitizes cells to oxidant injury. Virus research 2007;126(1-2):128-138.
  39. Ciccaglione AR, Stellacci E, Marcantonio C, Muto V, Marsili G, Rapicetta M, Battistini A. Repression of interferon regulatory factor 1 by hepatitis C virus core protein results in inhibition of antiviral and immunomodulatory genes [abstract]. Journal of clinical virology 2006;36(2 Suppl):S115.
  40. Ciccaglione AR, Costantino A, Tritarelli E, Marcantonio C, Equestre M, Marziliano N, Rapicetta M. Activation of endoplasmic reticulum stress response by hepatitis C virus proteins. Archives of virology 2005;150(7):1339-1356.
  41. Ciccaglione AR, Marcantonio C, Tritarelli E, Equestre M, Magurano F, Costantino A, Nicoletti L, Rapicetta M. The transmembrane domain of hepatitis C virus E1 glycoprotein induces cell death. Virus research 2004;104(1):1-9.
  42. Ciccaglione AR, Rapicetta M. A new channel protein from virus: the E1 protein of HCV. Current topics in virology 2003;3:147-153.
  43. Ciccaglione AR, Marcantonio C, Costantino A, Equestre M, Rapicetta M. Expression of HCV E1 protein in baculovirus-infected cells: effects on cell viability and apoptosis induction. Intervirology 2003;46(2):121-126.
  44. Ciccaglione AR, Costantino A, Marcantonio C, Equestre M, Geraci A, Rapicetta M. Mutagenesis of hepatitis C virus E1 protein affects its membrane-permeabilizing activity. Journal of general virology 2001;82(Pt 9):2243-2250.
  45. Ciccaglione AR, Marcantonio C, Costantino A, Equestre M, Geraci A, Rapicetta M. Expression and membrane association of hepatitis C virus envelope 1 protein. Virus genes 2000;21(3):223-226.
  46. Rapicetta M, Dettori S, Kondili LA, Chionne P, Ciccaglione AR, Miceli M, Mannella E. Persistence of HCV-RNA in a blood donor with negative antibody assays [letter]. Vox sanguinis 1999;76:192-193.
  47. Amoroso P, Rapicetta M, Tosti ME, Mele A, Spada E, Buonocore S, Lettieri G, Pierri G, Chionne P, Ciccaglione AR, Sagliocca L. Correlation between HCV genotype and chronicity rate in HCV acute hepatitis infection. Journal of hepatology 1998;28(6):939-944.
  48. Amoroso P, Rapicetta M, Tosti ME, Mele A, Spada E, Buonocore S, Lettieri G, Pierri P, Chionne P, Ciccaglione AR, Sagliocca L. Correlation between virus genotype and chronicity rate in acute hepatitis C. Journal of hepatology 1998;28:939-944.
  49. Spada E, Ciccaglione AR, Dettori S, Chionne P, Kondili LA, Amoroso P, Guadagnino V, Greco M, Rapicetta M. Genotyping HCV isolates from Italy by type-specific PCR assay in the core region. Research in virology 1998;149(4):209-218.
  50. Ciccaglione AR, Marcantonio C, Costantino A, Equestre M, Geraci A, Rapicetta M. Hepatitis C virus E1 protein induces modification of membrane permeability in E. coli cells. Virology 1998;250(1):1-8.
  51. Ciccaglione AR, Marcantonio C, Equestre M, Jones JM, Rapicetta M. Secretion and purification of HCV E1 protein forms as glutathione-S-transferase fusion in the baculovirus insect cell system. Virus research 1998;55(2):157-165.
  52. Bruni R, Argentini C, D'Ugo E, Giuseppetti R, Ciccaglione AR, Rapicetta M. Recurrence of WHV integration in the b3n locus in woodchuck hepatocellular carcinoma. Virology 1995;214(1):229-234.
  53. Ciccaglione AR, Rapicetta M, Fabiano A, Argentini C, Silvestro M, Giuseppetti R, Varano F, D'Urso N, Dinolfo L, Morgando A, Bruni R, Ponzetto A. Chronic infection in woodchucks infected by a cloned hepatitis delta virus. Archives of virology - Supplementum 1993;8(Suppl.):15-21.
  54. Simonetti RG, Cammà C, Fiorello F, Cottone M, Rapicetta M, Marino L, Fiorentino G, Craxì A, Ciccaglione AR, Giuseppetti R, Stroffolini T, Pagliaro L. Hepatitis C virus infection as a risk factor for hepatocellular carcinoma in patients with cirrhosis. A case-control study. Annals of internal medicine 1992;116(2):97-102.
  55. Rapicetta M, Stroffolini T, Ngatchu T, Chionne P, Ciccaglione AR, Lantum D, Chiaramonte M. Age- and sex-related study of HBV-DNA in HBsAg asymptomatic children from an endemic area (Cameroon). Annals of tropical paediatrics 1991;11(4):325-329.

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