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Personale dell'ISS

Umberto Agrimi

Dirigente di ricerca
+39 06 4990 3420
Viale Regina Elena 299
00161 - Roma (I)
umberto.agrimi@iss.it


Curriculum vitae

Direttore di Dipartimento SANV - Dipartimento sicurezza alimentare, nutrizione e sanità pubblica veterinaria

Pubblicazioni

  1. Di Bari MA, Nonno R, Castilla J, D'Agostino C, Pirisinu L, Riccardi G, Conte M, Richt J, Kunkle R, Langeveld JPM, Vaccari G, Agrimi U. Chronic wasting disease in bank voles: characterisation of the shortest incubation time model for prion diseases. PLoS pathogens 2013;9(3):e1003219.
  2. Migliore S, Esposito E, Pirisinu L, Marcon S, Di Bari MA, D'Agostino C, Chiappini B, Conte M, Sezzi E, De Grossi L, Agrimi U, Vaccari G, Nonno R. Effect of PrP genotype and route of inoculation on the ability of discriminatory Western blot to distinguish scrapie from sheep bovine spongiform encephalopathy. Journal of general virology 2012;93(Pt 2):450-455.
  3. Di Bari MA, Nonno R, Agrimi U. The mouse model for scrapie: inoculation, clinical scoring, and histopathological techniques. Methods in molecular biology 2012;849:453-471.
  4. Cosseddu GM, Nonno R, Vaccari G, Bucalossi C, Fernandez-Borges N, Di Bari MA, Castilla J, Agrimi U. Ultra-efficient PrP(Sc) amplification highlights potentialities and pitfalls of PMCA technology. PLoS pathogens 2011;7(11):e1002370.
  5. Pirisinu L, Migliore S, Di Bari MA, Esposito E, Baron T, D'Agostino C, De Grossi L, Vaccari G, Agrimi U, Nonno R. Molecular discrimination of sheep bovine spongiform encephalopathy from Scrapie. Emerging infectious diseases 2011;17(4):695-698.
  6. Bucalossi C, Cosseddu GM, D'Agostino C, Di Bari MA, Chiappini B, Conte M, Rosone F, De Grossi L, Scavia G, Agrimi U, Nonno R, Vaccari G. Assessment of the genetic susceptibility of sheep to scrapie by PMCA and comparison with experimental scrapie transmission studies. Journal of virology 2011;85(16):8386-8392.
  7. Pirisinu L, Di Bari MA, Marcon S, Vaccari G, D'Agostino C, Fazzi P, Esposito E, Galeno R, Langeveld JPM, Agrimi U, Nonno R. A new method for the characterization of strain-specific conformational stability of protease-sensitive and protease-resistant PrPSc. Plos One 2010;5(9):e12723.
  8. Colussi S, Vaccari G, Rasero R, Maroni Ponti A, Ru G, Sacchi P, Caramelli M, Agrimi U, Acutis P. Prospects for applying breeding for resistance to control scrapie in goats: The current situation in Italy. Small ruminant research 2010;88(2-3):97-101.
  9. Mazza M, Iulini B, Vaccari G, Acutis P, Martucci F, Esposito E, Peletto S, Barocci S, Chiappini B, Corona C, Barbieri I, Caramelli M, Agrimi U, Casalone C, Nonno R. Co-existence of classical scrapie and Nor98 in a sheep from an Italian outbreak. Research in veterinary science 2010;88(3):478-485.
  10. Vaccari G, Panagiotidis CH, Acin C, Peletto S, Barillet F, Acutis P, Bossers A, Langeveld JPM, van Keulen L, Sklaviadis T, Badiola JJ, Andréoletti O, Groschup MH, Agrimi U, Foster J, Goldmann W. State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology. Veterinary research 2009;40(5):48.
  11. Vaccari G, Scavia G, Sala M, Cosseddu GM, Chiappini B, Conte M, Esposito E, Lorenzetti R, Perfetti G, Marconi P, Scholl F, Barbaro K, Bella A, Nonno R, Agrimi U. Protective effect of the AT137RQ and ARQK176 PrP alleles against classical scrapie in Sarda breed sheep. Veterinary research 2009;40(3):19.
  12. Vetrugno V, Di Bari MA, Nonno R, Puopolo M, D'Agostino C, Pirisinu L, Pocchiari M, Agrimi U. Oral pravastatin prolongs survival time of scrapie-infected mice. Journal of general virology 2009;90(Pt 7):1775-1780.
  13. Carpinelli G, Canese R, Vetrugno V, Di Bari MA, Santoro F, Mei L, Sbriccoli M, Pocchiari M, Agrimi U, Podo F. T2-weighted MRI signal alterations in the early-clinical phase of transmissible spongiform encephalopathy in a scrapie rodent model. Magnetic resonance insights 2009;3:1-9.
  14. Agrimi U, Nonno R, Dell'Omo G, Di Bari MA, Conte M, Chiappini B, Esposito E, Di Guardo G, Windl O, Vaccari G, Lipp HP. Prion protein amino acid determinants of differential susceptibility and molecular feature of prion strains in mice and voles. PLoS pathogens 2008;4(7):e1000113.
  15. Colussi S, Vaccari G, Maurella C, Bona C, Lorenzetti R, Troiano P, Casalinuovo F, Di Sarno A, Maniaci MG, Zuccon F, Nonno R, Casalone C, Mazza M, Ru G, Caramelli M, Agrimi U, Acutis P. Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats. Journal of general virology 2008;89(Pt 12):3173-3176.
  16. Zanusso G, Polo A, Farinazzo A, Nonno R, Cardone F, Di Bari MA, Ferrari S, Principe S, Gelati M, Fasoli E, Fiorini M, Prelli F, Frangione B, Tridente G, Bentivoglio M, Giorgi A, Schininà ME, Maras B, Agrimi U, Rizzuto N, Pocchiari M, Monaco S. Novel prion protein conformation and glycotype in Creutzfeldt-Jakob disease. Archives of neurology 2007;64(4):595-599.
  17. Vaccari G, D'Agostino C, Nonno R, Rosone F, Conte M, Di Bari MA, Chiappini B, Esposito E, De Grossi L, Giordani F, Marcon S, Morelli L, Borroni R, Agrimi U. Prion protein alleles showing a protective effect on the susceptibility of sheep to scrapie and bovine Spongiform encephalopathy. Journal of virology 2007;81(13):7306-7309.
  18. Bruce ME, Nonno R, Foster J, Goldmann W, Di Bari MA, Esposito E, Benestad SL, Hunter N, Agrimi U. Nor98-like sheep scrapie in the United Kingdom in 1989. Veterinary record 2007;160(19):665-666.
  19. Nonno R, Di Bari MA, Cardone F, Vaccari G, Fazzi P, Dell'Omo G, Cartoni C, Ingrosso L, Boyle A, Galeno R, Sbriccoli M, Lipp HP, Bruce ME, Pocchiari M, Agrimi U. Efficient transmission and characterization of Creutzfeldt-Jakob disease strains in bank voles. PLoS pathogens 2006;2(2):e12.
  20. Piening N, Nonno R, Di Bari MA, Walter S, Windl O, Agrimi U, Kretzschmar HA, Bertsch U. Conversion efficiency of bank vole prion protein in vitro is determined by residues 155 and 170, but does not correlate with the high susceptibility of bank voles to sheep scrapie in vivo. Journal of biological chemistry 2006;281(14):9373-9384.
  21. Vaccari G, Di Bari MA, Morelli L, Nonno R, Chiappini B, Antonucci G, Marcon S, Esposito E, Fazzi P, Palazzini N, Troiano P, Petrella A, Di Guardo G, Agrimi U. Identification of an allelic variant of the goat PrP gene associated with resistance to scrapie. Journal of general virology 2006;87(Pt 5):1395-1402.
  22. Pasquali P, Nonno R, Mandara MT, Di Bari MA, Ricci G, Petrucci P, Capuccini S, Cartoni C, Macrì A, Agrimi U. Intracerebral administration of Interleukin-12 (IL-12) and IL-18 modifies the course of mouse scrapie. BMC veterinary research 2006;2:37.
  23. Cartoni C, Schininà ME, Maras B, Nonno R, Vaccari G, Di Bari MA, Conte M, Liù Q, Lu M, Cardone F, Windl O, Pocchiari M, Agrimi U. Identification of the pathological prion protein allotypes in scrapie-infected heterozygous bank voles (Clethrionomys glareolus) by high-performance liquid chromatography–mass spectrometry. Journal of chromatography A 2005;1081(1):122-126.
  24. Uboldi C, Del Vecchio I, Foti MG, Azzalin A, Paulis M, Raimondi E, Vaccari G, Agrimi U, Di Guardo G, Comincini S, Ferretti L. Prion-like Doppel gene (PRND) in the goat: genomic structure, cDNA, and polymorphisms. Mammalian genome 2005;16(12):963-971.
  25. Vascellari M, Aufiero GM, Nonno R, Agrimi U, Vaccari G, Basilicata L, Falcaro C, Mancin M, Marcon S, Mutinelli F. Diagnosis and PrP genotype target of scrapie in clinically healthy sheep of Massese breed in the framework of a scrapie eradication programme. Archives of virology 2005;150(10):1959-1976.
  26. Di Guardo G, Marruchella G, Agrimi U, Kennedy S. Morbillivirus infections in aquatic mammals: a brief overview. Journal of veterinary medicine. Series A 2005;52:88-93.
  27. Chiappini B, Brambilla G, Agrimi U, Vaccari G, Aarts HJM, Berben G, Frezza D, Giambra V. Real-time polymerase chain reaction approach for quantitation of ruminant-specific DNA to indicate a correlation between DNA amount and meat and bone meal heat treatments. Journal of AOAC International 2005;88(5):1399-1403.
  28. Di Guardo G, Della Salda L, Marruchella G, Terracciano G, Agrimi U. Immunohistochemistry and morbillivirus infections in sea mammals. Microscopy and analysis 2004;18(3):25-27.
  29. Ligios C, Viglietti A, Carta P, Dexter G, Agrimi U, Simmons M. Clinicopathological findings in sheep from Sardinia showing neurological signs of disease. Veterinary record 2004;154(12):365-370.
  30. Vaccari G, Conte M, Morelli L, Di Guardo G, Petraroli R, Agrimi U. Primer extension assay for prion protein genotype determination in sheep. Molecular and cellular probes 2004;18(1):33-37.
  31. Nonno R, Esposito E, Vaccari G, Conte M, Marcon S, Di Bari MA, Ligios C, Di Guardo G, Agrimi U. Molecular analysis of cases of Italian sheep scrapie cases and comparison with cases of bovine spongiform encephalopathy (BSE) and experimental BSE in sheep. Journal of clinical microbiology 2003;41(9):4127-4133.
  32. Frezza D, Favaro M, Vaccari G, von-Holst C, Giambra V, Anklam E, Bove D, Battaglia PA, Agrimi U, Brambilla G, Ajmone-Marsan P, Tartaglia M. A competitive polymerase chain reaction-based approach for the identification and semiquantification of mitochondrial DNA in differently heat-treated bovine meat and bone meal. Journal of food protection 2003;66(1):103-109.
  33. Frezza D, Favaro M, Vaccari G, von-Holst C, Giambra V, Anklam E, Bove D, Battaglia PA, Agrimi U, Brambilla G, Ajmone-Marsan P, Tartaglia M. A competitive polymerase chain reaction-based approach for the identification and semiquantification of mitochondrial DNA in differently heat-treated bovine meat and bone meal. Journal of food protection 2003;66(1):103-109.
  34. Agrimi U, Conte M, Morelli L, Di Bari MA, Di Guardo G, Ligios C, Antonucci G, Aufiero GM, Pozzato N, Mutinelli F, Nonno R, Vaccari G. Animal transmissible spongiform encephalopathies and genetics. Veterinary research communications 2003;27(Suppl 1):31-38.
  35. Mutinelli F, Aufiero GM, Pozzato N, Marangon S, Agrimi U, Vaccari G, Vincenzi G. Eradication of scrapie in a Massese sheep flock by PrP allele selection [letter]. Veterinary record 2003;152(2):60.
  36. Dell'Omo G, Vannoni E, Vyssotski AL, Di Bari MA, Nonno R, Agrimi U, Lipp HP. Early behavioural changes in mice infected with BSE and scrapie: automated home cage monitoring reveals prion strain differences. European journal of neuroscience 2002;16(4):735-742.
  37. Vaccari G, Petraroli R, Agrimi U, Eleni C, Perfetti M, Di Bari MA, Morelli L, Ligios C, Busani L, Nonno R, Di Guardo G. PrP genotype in Sarda breed sheep and its relevance to scrapie. Archives of virology 2001;146(10):2029-2037.
  38. Agrimi U, Ru G, Cardone F, Pocchiari M, Caramelli M. Epidemic of transmissible spongiform encephalopathy in sheep and goats in Italy. Lancet 1999;353(9152):560-561.
  39. Fattorini L, Mattei M, Placido R, Li B, Iona E, Agrimi U, Colizzi V, Orefici G. Mycobacterium avium infection in BALB/c and SCID mice. Journal of medical microbiology 1999;48:577-583.
  40. Battisti A, Di Guardo G, Agrimi U, Panfili G, Bozzano AI. Embrionic and neonatal motality from salmonellosis in captive bred raptors. Journal of wildlife diseases 1998;34(1):64-72.
  41. Dell'Omo G, Morabito S, Quondam R, Agrimi U, Ciuchini F, Macrì A, Caprioli A. Feral pigeons as a source of verocytotoxin-producing Escherichia coli. Veterinary record 1998;142(12):309-310.
  42. Malatesta T, Frati R, Cerioni S, Agrimi U, Di Guardo G. Ogmogastet-antarcticus Johnston, 1931 (Digenea: Notocotylidae) in Balaenoptera physalus (L.): first record in the Mediterranean sea. Systematic parasitology 1998;40:63-66.
  43. Agrimi U, Di Guardo G. Approccio allo studio e alla gestione delle zoonosi trasmesse dagli animali selvatici. Annali dell'Istituto Superiore di Sanità 1997;33(02):251-257.
  44. Pocchiari M, Ingrosso L, Cardone F, Ladogana A, Eleni C, Agrimi U. Effect of amphotericin B on 263K and 139H strains of scrapie in Armenian hamsters. In: Court L, Dodet B, ed. Transmissible subacute spongiform encephalopathies: prion diseas Paris: Elsevier; 1996. p.185-190.
  45. Guarda F, Castiglione F, Agrimi U, Cardone F, Caracappa S, Pocchiari M. Bovine spongiform encephalopathy in Italy. European journal of veterinary pathology 1995;1(2):71-72.
  46. Pocchiari M, Vetrugno V, Ingrosso L, Xi YG, Agrimi U. Attemps at maternal transmission of scrapie in hamsters. A consultation on BSE with the scientific Veterinary Committee of the Commission of the European Communities. In: ; September 14-15, 1993; Brussels. 1994. p.183-187.
  47. Agrimi U, Di Guardo G. Amyloid, amyloid-inducers, cytokines and heavy metals in scrapie and other human and animal subacute spongiform encephalopathies: some hypotheses. Medical hypotheses 1993;40(2):113-116.
  48. Agrimi U, Morelli L, Di Guardo G. Squamous cell carcinoma of the skin in a Pere David's deer (Elaphurus davidianus). Journal of wildlife diseases 1993;29(4):616-617.
  49. Agrimi U, Di Guardo G, Pocchiari M. Bovine spongiform encephalopathy: an overview. Annali dell'Istituto Superiore di Sanità 1992;28(04):497-505.

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