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Personale dell'ISS

Paolo Pasquali

Primo ricercatore
+39 06 4990 2326
Viale Regina Elena 299
00161 - Roma (I)
pasquali@iss.it


Curriculum vitae

Pubblicazioni

  1. Chirullo B, Ammendola S, Leonardi L, Falcini R, Petrucci P, Pistoia C, Vendetti S, Battistoni A, Pasquali P. Attenuated mutant strain of Salmonella Typhimurium lacking the ZnuABC transporter contrasts tumor growth promoting anti-cancer immune response. Oncotarget 2015;6(19):17648-17660.
  2. Chirullo B, Pesciaroli M, Drumo R, Ruggeri J, Razzuoli E, Pistoia C, Petrucci P, Martinelli N, Cucco L, Moscati L, Amadori M, Magistrali C, Alborali GL, Pasquali P. Salmonella Typhimurium exploits inflammation to its own advantage in piglets. Frontiers in microbiology 2015;6:985.
  3. D'Orazio M, Mastropasqua MC, Cerasi M, Pacello F, Consalvo A, Chirullo B, Mortensen B, Skaar EP, Ciavardelli D, Pasquali P, Battistoni A. The capability of Pseudomonas aeruginosa to recruit zinc under conditions of limited metal availability is affected by inactivation of the ZnuABC transporter. Metallomics 2015;7(6):1023-1035.
  4. Grilli E, Foresti F, Tugnoli B, Fustini M, Zanoni M, Pasquali P, Callaway TR, Piva A, Alborali GL. Microencapsulated sorbic acid and pure botanicals affect Salmonella typhimurium shedding in pigs: a close-up look from weaning to slaughter in controlled and field conditions. Foodborne pathogens and disease 2015;12(10):813-819.
  5. Ruggeri J, Pesciaroli M, Foresti F, Giacomini E, Lazzaro M, Ossiprandi MC, Corradi A, Lombardi G, Pasquali P, Alborali GL. Inactivated Salmonella enterica serovar Typhimurium monophasic variant (S. Typhimurium 1,4,[5],12:i-) in sows is effective to control infection in piglets under field condition. Veterinary microbiology 2015;180(1-2):82-89.
  6. Mancini FR, Bella A, Graziani C, Marianelli C, Mughini Gras L, Pasquali P, Pompa MG, Rizzo C, Rizzuto E, Busani L. Trends of human brucellosis in Italy, 1998-2010. Epidemiology and infection 2014;142(6):1188-1195.
  7. Pérez-Sancho M, Adone R, García-Seco T, Tarantino M, Diez-Guerrier A, Drumo R, Francia M, Domínguez L, Pasquali P, Álvarez J. Evaluation of the immunogenicity and safety of Brucella melitensis B115 vaccination in pregnant sheep. Vaccine 2014;32(16):1887-1881.
  8. Cerasi M, Liu JZ, Ammendola S, Poe AJ, Petrarca P, Pesciaroli M, Pasquali P, Raffatellu M, Battistoni A. The ZupT transporter plays an important role in zinc homeostasis and contributes to Salmonella enterica virulence. Metallomics 2014;6(4):845-853.
  9. Ruggeri J, Pesciaroli M, Gaetarelli B, Scaglione Frine E, Pregel P, Ammendola S, Battistoni A, Bollo E, Alborali L, Pasquali P. Parenteral administration of attenuated Salmonella Typhimurium ?znuABC is protective against salmonellosis in piglets. Vaccine 2014;32(32):4032-4038.
  10. Alfano F, Peletto S, Lucibelli MG, Borriello G, Urciuolo G, Maniaci MG, Desiato R, Tarantino M, Barone A, Pasquali P, Acutis P, Galiero G. Identification of single nucleotide polymorphisms in Toll-like receptor candidate genes associated with tuberculosis infection in water buffalo (Bubalus bubalis). BMC genetics 2014;15(1):139.
  11. Pesciaroli M, Álvarez J, Boniotti MB, Cagiola M, Di Marco V, Marianelli C, Pacciarini ML. Tuberculosis in domestic animal species. Research in veterinary science 2014;97(Suppl):S78-S85.
  12. Gradassi M, Pesciaroli M, Martinelli N, Ruggeri J, Petrucci P, Hassam WH, Raffatellu M, Scaglione Frine E, Ammendola S, Battistoni A, Alborali GL, Pasquali P. Attenuated Salmonella enterica serovar Typhimurium lacking the ZnuABC transporter: an efficacious orally-administered mucosal vaccine against salmonellosis in pigs. Vaccine 2013;31(36):3695-3701.
  13. Pesciaroli M, Gradassi M, Martinelli N, Ruggeri J, Pistoia C, Raffatellu M, Magistrali C, Battistoni A, Pasquali P, Alborali GL. Salmonella Typhimurium lacking the ZnuABC transporter is attenuated and immunogenic in pigs. Vaccine 2013;31(27):2868-2873.
  14. Adone R, Pasquali P. Epidemiosurveillance of brucellosis. Revue scientifique et technique de l'Office International des Epizooties 2013;32(1):199-205.
  15. Pesciaroli M, Russo M, Mazzone P, Aronica V, Fiasconaro M, Boniotti MB, Corneli S, Cagiola M, Pacciarini ML, Di Marco V, Pasquali P. Evaluation of the interferon-gamma (IFN-?) assay to diagnose Mycobacterium bovis infection in pigs. Veterinary immunology and immunopathology 2012;148(3-4):369-372.
  16. Liu JZ, Jellbauer S, Poe A, Pesciaroli M, Kehl-Fie TE, Restrepo NA, Hosking MP, Edwards RA, Battistoni A, Pasquali P, Lane TE, Chazin WJ, Vogl T, Roth J, Skaar EP, Raffatellu M. Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflammed gut. Cell host & microbe 2012;11(3):227-239.
  17. Di Marco V, Mazzone P, Capucchio MT, Boniotti MB, Aronica V, Russo M, Fiasconaro M, Cifani N, Corneli S, Biasibetti E, Biagetti M, Pacciarini ML, Cagiola M, Pasquali P, Marianelli C. Epidemiological significance of the domestic black pig (Sus scrofa) in maintenance of bovine tuberculosis in Sicily. Journal of clinical microbiology 2012;50(4):1209-1218.
  18. Adone R, Francia M, Pistoia C, Petrucci P, Pesciaroli M, Pasquali P. Protective role of antibodies induced by Brucella melitensis B115 against B. melitensis and Brucella abortus infections in mice. Vaccine 2012;30(27):3992-3995.
  19. Borriello G, Lucibelli MG, Pesciaroli M, Carullo MR, Graziani C, Ammendola S, Battistoni A, Ercolini D, Pasquali P, Galiero G. Diversity of Salmonella spp. serovars isolated from the intestines of water buffalo calves with gastroenteritis. BMC veterinary research 2012;8:201.
  20. Foster N, Berndt A, Lalmanach A, Methner U, Pasquali P, Rychlik I, Velge P, Zhou X, Barrow P. Emergency and therapeutic vaccination - Is stimulating innate immunity an option ? Research in veterinary science 2012;93(1):7-12.
  21. Adone R, Francia M, Pistoia C, Pesciaroli M, Pasquali P. B. melitensis rough strain B115 is protective against heterologous Brucella spp. infections. Vaccine 2011;29(14):2523-2529.
  22. Pesciaroli M, Aloisio F, Ammendola S, Tarantino M, Pistoia C, Petrucci P, Francia M, Battistoni A, Pasquali P. An attenuated Salmonella enterica serovar Typhimurium strain lacking the ZnuABC transporter induces protection in a mouse intestinal model of Salmonella infection. Vaccine 2011;29(9):1783-1790.
  23. Sturniolo G, Mondello P, Bruno S, Bonfatto OE, Frattima S, Albanese A, Restivo R, Liberti G, Pasquali P, Marianelli C. Neurobrucellosis associated with syndrome of inappropriate antidiuretic hormone with resultant diabetes insipidus and hypothyroidism. Journal of clinical microbiology 2010;48:3806-3809.
  24. Vendetti S, Davidson TS, Veglia F, Riccomi A, Negri DRM, Lindstedt R, Pasquali P, Shevach EM, De Magistris MT. Polyclonal Treg cells enhance the activity of a mucosal adjuvant. Immunology and cell biology 2010;88(7):698-706.
  25. Petrarca P, Ammendola S, Pasquali P, Battistoni A. The Zur-regulated ZinT protein is an auxiliary component of the high-affinity ZnuABC zinc transporter that facilitates metal recruitment during severe zinc shortage. Journal of bacteriology 2010;192(6):1553-1564.
  26. Pasquali P, Thornton A, Vendetti S, Pistoia C, Petrucci P, Tarantino M, Pesciaroli M, Ruggeri FM, Battistoni A, Shevach EM. CD4+CD25+ T regulatory cells limit effector T cells and favor the progression of brucellosis in BALB/c mice. Microbes and infection 2010;12(1):3-10.
  27. Marianelli C, Cifani N, Pasquali P. Evaluation of antimicrobial activity of probiotic bacteria against Salmonella enterica subsp. enterica serovar typhimurium 1344 in a common medium at different environmental conditions. Research in microbiology 2010;161(8):673-680.
  28. Marianelli C, Cifani N, Capucchio MT, Fiasconaro M, Russo M, La Mancusa F, Pasquali P, Di Marco V. A case of generalized bovine tuberculosis in a sheep. Journal of veterinary diagnostic investigation 2010;22(3):445-448.
  29. Tarantino M, Dionisi AM, Pistoia C, Petrucci P, Luzzi I, Pasquali P. Involvement of nitric oxide in the control of a mouse model of Campylobacter jejuni infection. FEMS immunology and medical microbiology 2009;56(1):98-101.
  30. Russo G, Pasquali P, Nenova R, Alexandrov T, Ralchev S, Vullo V, Rezza G. Reemergence of human and animal brucellosis in Bulgaria. Emerging infectious diseases 2008;15(2):314-316.
  31. Ammendola S, Pasquali P, Pacello F, Rotilio G, Castor M, Libby SJ, Figueroa BN, Bossi L, Fang FC, Battistoni A. Regulatory and structural differences in the Cu,Zn-superoxide dismutases of Salmonella enterica and their significance for virulence. Journal of biological chemistry 2008;283(20):13688-13699.
  32. Marianelli C, Petrucca A, Pasquali P, Ciuchini F, Styliani P, Cipriani P. Use of MLVA-16 typing to trace the source of a laboratory-acquired Brucella infection [letter]. Journal of hospital infection 2008;68(3):274-276.
  33. Pacello F, Ceci P, Ammendola S, Pasquali P, Chiancone E, Battistoni A. Periplasmic Cu,Zn superoxide dismutase and cytoplasmic Dps concur in protecting Salmonella enterica serovar Typhimurium from extracellular reactive oxygen species. Biochimica et biophysica acta-general subjects 2008;1780(2):226-232.
  34. Pasquali P, Ammendola S, Pistoia C, Petrucci P, Tarantino M, Valente C, Marenzoni ML, Rotilio G, Battistoni A. Attenuated Salmonella enterica serovar Typhimurium lacking the ZnuABC transporter confers immune-based protection against challenge infections in mice. Vaccine 2008;26(27-28):3421-3426.
  35. Cagiola M, Severi G, Forti K, Menichelli M, Papa P, De Giuseppe A, Pasquali P. Abortion due to Salmonella enterica serovar abortusovis (S. Abortusovis) in ewes is associated to a lack of production of IFN-? and can be prevented by immunization with inactivated S. Abortusovis vaccine. Veterinary microbiology 2007;121(3-4):330-337.
  36. Ammendola S, Pasquali P, Pistoia C, Petrucci P, Petrarca P, Rotilio G, Battistoni A. High affinity Zn2+ uptake system ZnuABC is required for bacterial zinc homeostasis in intracellular environments and contributes to virulence of Salmonella enterica. Infection and immunity 2007;75(12):5867-5876.
  37. Marianelli C, Ciuchini F, Tarantino M, Pasquali P, Adone R. Molecular characterization of the rpoB gene in Brucella species: new potential molecular markers for genotyping. Microbes and infection 2006;8:860-865.
  38. Cagiola M, Severi G, Menichelli M, Forti K, Petrucci P, Macrì A, Pasquali P. In vitro down regulation of proinflammatory cytokines induced by LPS tolerance in pig CD14+cells. Veterinary immunology and immunopathology 2006;112(3-4):316-320.
  39. Pasquali P, Fayer R, Zarlenga D, Canals A, de Marez T, Gomez Munoz TM, Almeria S, Gasbarre LC. Recombinant bovine interleukin-12 stimulates a gut immune response but does not provide resistance to Cryptosporidium parvum infection in neonatal claves. Veterinary parasitology 2006;135:259-268.
  40. Adone R, Ciuchini F, Marianelli C, Tarantino M, Pistoia C, Marcon G, Petrucci P, Francia M, Riccardi G, Pasquali P. Protective properties of rifampin-resistant rough mutants of Brucella melitensis. Infection and immunity 2005;73(7):4198-4204.
  41. Pasquali P, Zalcman A, Murtas S, Adone R, Brambilla G, Marianelli C, Cagiola M, Ciuchini F. In vitro stimulation of murine peritoneal monocytes induced by alginates. Archives of pharmacal research 2005;28(8):936-941.
  42. Ammendola S, Ajello M, Pasquali P, Kroll JS, Langford PR, Rotilio G, Valenti P, Battistoni A. Differential contribution of sodC1 and sodC2 to intracellular survival and pathogenicity of Salmonella enterica serovar Choleraesuis. Microbes and infection 2005;7(4):698-707.
  43. Cagiola M, Feliziani F, Severi G, Pasquali P, Rutili D. Analysis of possible factors affecting the specificity of the gamma interferon test in tuberculosis-free cattle herds. Clinical and diagnostic laboratory immunology 2004;11(5):952-956.
  44. Marianelli C, Ciuchini F, Tarantino M, Pasquali P, Adone R. Genetic bases of rifampin resistance phenotype in Brucella spp. Journal of clinical microbiology 2004;42(12):5439-5443.
  45. Gomez Munoz TM, Canals-Caballero A, Almeria S, Pasquali P, Zarlenga D, Gasbarre LC. Inhibition of bovine T lymphocyte responses by extracts of the stomach worm Ostertagia ostertagi. Veterinary parasitology 2004;120(3):199-214.
  46. Pasquali P, Adone R, Pistoia C, Petrucci P, Ciuchini F. Brucella abortus RB51 induces protection in mice orally infected with virulent strain B. abortus 2308. Infection and immunity 2003;71(5):2326-2330.
  47. Piergili Fioretti D, Pasquali P, Diaferia M, Mangili V, Rosignoli L. Neospora caninum infection and congenital transmission: serological and parasitological study of cows up to the fourth gestation. Journal of veterinary medicine series B-infectious diseases and veterinary 2003;50:399-404.
  48. Marianelli C, La Rosa G, Ciuchini F, Muscillo M, Pasquali P, Adone R. Genetic diversity at alkB locus in Brucella abortus. Journal of veterinary medicine series B-infectious diseases and veterinary 2003;50(10):494-499.
  49. Adone R, Ciuchini F, Pistoia C, Pasquali P. Combined S99/RB51 antigen for complement fixation test for serological diagnosis of brucellosis in cattle and sheep. Journal of applied microbiology 2002;93(5):872-876.
  50. Ciuchini F, Adone R, Pasquali P. Coombs antiglobulin test using Brucella abortus 99 as antigen to detect incomplete antibodies induced by B. abortus RB51 vaccine in cattle. Clinical and diagnostic laboratory immunology 2002;9(6):1398-1399.
  51. Pasquali P, Adone R, Gasbarre LC, Pistoia C, Ciuchini F. Effect of exogenous interleukin-18 (IL-18) and IL-12 in the course of Brucella abortus 2308 infection in mice. Clinical and diagnostic laboratory immunology 2002;9(2):491-492.
  52. Adone R, Pasquali P, La Rosa G, Marianelli C, Muscillo M, Fasanella A, Francia M, Ciuchini F. Sequence analysis of the genes encoding for the major virulence factors of Bacillus anthracis vaccine strain "Carbosap". Journal of applied microbiology 2002;93(1):117-121.
  53. Pasquali P, Adone R, Gasbarre LC, Pistoia C, Ciuchini F. Mouse cytokine profiles associated with Brucella abortus RB51 vaccination or B. abortus 2308 infection. Infection and immunity 2001;69(10):6541-6544.

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