According to the ISS Presidential Decree of January 24, 2003 concerning the Organization of the Institute and its personnel ("Regolamento recante norme per l'organizzazione strutturale e la disciplina del rapporto di lavoro dei dipendenti dell'Istituto superiore di sanità"):
Technical-Scientific Services
Central Directorates
National Centres
Departments
Board of Auditors
Scientific Committee
Director General
Board of Directors
President