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ISS : Chi siamo : Personale dell'ISS : Ugo Testa 

Ugo Testa 
Dirigente di ricerca

Telefono:  +39 06 4990 2422
Viale Regina Elena 299
00161 - Roma (I)
ugo.testa@iss.it

Pubblicazioni

  1. Rizzo MG, Giombini E, Diverio D, Vignetti M, Sacchi A, Testa U, LoCoco F, Blandino G. Analysis of p73 expression pattern in acute myeloid leukemias: lack of DeltaN-p73 expression is a frequent feature of acute promyelocytic leucemia. Leukemia 2004;18(11):1804-1809.
  2. Testa U, Riccioni R, Diverio D, Rossini A, Lococo E, Peschle C. Interleukin-3 receptor in acute leukemia. Leukemia 2004;18(2):219-226.
  3. Testa U, Stellacci E, Pelosi E, Sestili P, Venditti M, Orsatti R, Fragale A, Petrucci E, Pasquini L, Belardelli F, Gabriele L, Battistini A. Impaired myelopoiesis in mice devoid of interferon regulatory factor 1. Leukemia 2004;18(11):1864-1871.
  4. Calzolari A, Deaglio S, Sposi NM, Petrucci E, Morsilli O, Gabbianelli M, Malavasi F, Testa U, Peschle C. Transferrin receptor 2 protein is not expressed in normal erythroid cells. Biochemical journal 2004;381(Pt 3):629-634.
  5. Stellacci E, Testa U, Petrucci E, Benedetti E, Orsatti R, Feccia T, Stafsnes M, Coccia EM, Marziali G, Battistini A. Interferon regulatory factor-2 drives megakaryocytic differentiation. Biochemical journal 2004;377(2):367-378.
  6. Riccioni R, Rossini A, Calabrò L, Diverio D, Pasquini L, LoCoco F, Peschle C, Testa U. Immunophenotypic features of acute myeloid leukemias overexpressing the interleukin 3 receptor alpha chain. Leukemia & Lymphoma 2004;45(8):1511-1517.
  7. Testa U. Interleukin-3 receptor as a target for antileukemic drugs. Drugs of the future 2004;29(8):821-833.
  8. Galli MC, Carè A, Cianfriglia M, Crescenzi M, Dogliotti E, Federico M, Testa U. Linee guida sulla sperimentazione clinica di fase I con medicinali sperimentali per terapia genica somatica. Notiziario dell'Istituto Superiore di Sanità 2004;17(07-08):15-27.
  9. Migliaccio G, Testa U, Cometa MF, Fais S, Chistolini P, Bignami M, Agrimi U, Proietti E, Coccia EM. Linee guida sui prodotti per terapia cellulare. Notiziario dell'Istituto Superiore di Sanità 2004;17(07-08):9-14.
  10. Pernotti E, Ilari R, Morsilli O, Testa U, Marziali G, Battistini A. Role of ETS-1 in transcriptional regulation of transferrin receptor. In: Fenton MJ, ed. 5. Joint Meeting of International Cytokine Society (ICS) and International Society for Interferon and Cytokine Research (ISICR). San Juan (Puerto Rico), October 21-25, 2004. Proceedings Bologna: Monduzzi editore; 2004. p.97-101.
  11. Stellacci E, Testa U, Battistini A. IRF-1 and IRF-2 drive specific lineage development during myeloid differentiation. In: Fenton MJ, ed. 5. Joint Meeting of International Cytokine Society (ICS) and International Society for Interferon and Cytokine Research (ISICR). San Juan (Puerto Rico), October 21-25, 2004. Proceedings Bologna: Monduzzi editore; 2004. p.91-95.
  12. Testa U, Rossini A, Riccioni R, Peschle C. Molecular abnormalities of acute leukemias. In: Guerra R, Marzolini A, ed. 7. International conference Sino-Italian health days. Istituto Superiore di Sanità. Rome, April 3-4, 2003. Proceedings. Roma: Istituto Superiore di Sanità; 2004. (Rapporti ISTISAN 04/17). p.8-14.
  13. Testa U. Apoptotic mechanisms in the control of erythropoiesis. Leukemia Journal 2004;18(7):1176-1199.
  14. Casella I, Feccia T, Chelucci C, Samoggia P, Castelli G, Guerriero R, Parolini I, Petrucci E, Pelosi E, Morsilli O, Gabbianelli M, Testa U, Peschle C. Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt1 receptor. Blood 2003;101(4):1316-1323.
  15. Coppola S, Narciso L, Pelosi E, Cerio AM, Morsilli O, Bonci D, Gabbianelli M, De Maria R, Testa U, Peschle C. KDR stimulation by VEGF promotes megakaryotyic differentation and maturation in normal and leukemic CD34+ hematopoietic progenitor cells [abstract]. Blood 2003;102(11):828a.
  16. Gabbianelli M, Testa U, Massa A, Morsilli O, Saulle E, Sposi NM, Petrucci E, Mariani G, Peschle C. HbF reactivation in sibling BFU-E colonies: synergistic interaction of kit ligand with low dose dexamethasone. Blood 2003;101(7):2826-32.
  17. Zeuner A, Pedini F, Signore M, Testa U, Peschle C, De Maria R. Stem cell factor erythroid precursor cells from chemotherapeutic agents via up-regulation of BCL-2 family proteins. Blood 2003;102(1):87-93.
  18. Riccioni R, Saulle E, Militi S, Sposi NM, Mariani G, Nanni M, Mancini M, Diviero D, Lo Coco F, Peschle C, Testa U. C-fms expression correlates with monocytic differentiation in PML-RARalfa+ acute promyelocytic leukemia. Leukemia 2003;17(1):98-113.
  19. Guerriero R, Gabbianelli M, Parolini I, Samoggia P, Petrucci E, Sargiacomo M, Chelucci C, Testa U, Peschle C. Inhibition of TPO-induced MAPK activity increases polyploidization in human differentiating MK progenitor cells. In: 43. Annual Meeting of the American Society for Cell Biology. Abstracts; December 13-17, 2003; San Francisco. 2003.
  20. Marziali G, Testa U. Il DNA: contributo allo studio del differenziamento cellulare. Notiziario dell'Istituto Superiore di Sanità 2003;16(02):9-11.
  21. Testa U, Riccioni R, Rossini A, Diverio D, Labbaye C, Quaranta MT, Spinello I, Lo Coco F, Peschle C. Cytokine receptor signaling in acute myleloid Leukemia [abstract]. Haematologica 2003;88 (Suppl.15):12-13.
  22. Testa U. La scoperta del DNA e i tumori. Notiziario dell'Istituto Superiore di Sanità 2003;16(02):12-14.
  23. Pelosi E, Valtieri M, Coppola S, Botta R, Gabbianelli M, Lulli V, Marziali G, Masella B, Muller R, Sgadari C, Testa U, Bonanno G, Peschle C. Identification of the hemangioblast in postnatal life. Blood 2002;100(9):3203-3208.
  24. Testa U, Riccioni R, Militi S, Stellacci E, Samoggia P, Latagliata R, Mariani G, Rossini A, LoCoco F, Peschle C. Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis. Blood 2002;100(8):2980-2988.
  25. Testa U, Torelli GF, Riccioni R, Onetti Muta A, Militi S, Annino L, Mariani G, Guarini A, Chiaretti S, Ritz J, Mandelli F, Peschle C, Foa R. Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors. Blood 2002;99(12):4634-4637.
  26. Testa U. Platelet formation: a link between apoptosis and differentiation. Blood 2002;100(4):1111-1112.
  27. Labbaye C, Quaranta MT, Pagliuca A, Militi S, Licht JD, Testa U, Peschle C. PLZF induces megakaryocytic development, activates TPO receptor expression and interacts with GATA1 protein. Oncogene 2002;21(43):6669-6679.
  28. Marziali G, Perrotti E, Ilari R, Lulli V, Coccia EM, Moret R, Kuhn LC, Testa U, Battistini A. Role of Ets-1 in transcriptional regulation of transferrin receptor and erythroid differentiation. Oncogene 2002;21(52):7933-7944.
  29. Giampaolo A, Felli N, Diverio D, Morsilli O, Samoggia P, Breccia M, Lo Coco F, Peschle C, Testa U. Expression pattern of HOXB6 homeobox gene in myelomonocytic differentiation and acute myeloid leukemia. Leukemia 2002;16(7):1293-1301.
  30. Bonsignore MR, Morici G, Santoro A, Pagano M, Cascio L, Bonanno A, Abate P, Mirabella F, Profita M, Insalaco G, Gioia M, Vignola MA, Majolino I, Testa U, Hogg JC. Circulating hematopoietic progenitor cells in runners. Journal of applied physiology 2002;93(5):1691-1697.
  31. Sposi NM, Rossini A, Cianetti L, Pasquini L, Petrucci E, Saulle E, Morsilli O, Gabbianelli M, Testa U. Expression and function of NRAMP2 and ferroportin-1 genes during hemopoietic differentiation [abstract]. International journal of molecular medicine 2002;10(Suppl. 1):S85.
  32. Testa U, Stellacci E, Pelosi E, Sestili P, Venditti M, Orsatti R, Petrucci E, Belardelli F, Gabriele L, Battistini A. Mice devoid of interferon regulatory factor 1 show an impaired granulopoiesis. In: Journal of interferon and cytokine research; October 6-10, 2002; Turin. New York: Mary Ann Liebert; 2002. p.S-140.
  33. Testa U, Stellacci E, Petrucci E, Benedetti E, Orsatti R, Feccia T, Coccia EM, Marziali G, Battistini A. Forced IRF-2 expression in murine promyelocytic cell line 32DC13: induction of TPO receptor and megakaryocytic differentiation. In: Journal of interferon and cytokine research; October 6-10, 2002; Turin. New York: Mary Ann Liebert; 2002. p.S-140.
  34. Marziali G, Perrotti E, Ilari R, Lulli V, Mazzeo S, Kuhn LC, Testa U. Role of Ets-1 in erythroid differentiation. Blood cells, molecules and diseases 2002;29(3):553-561.
  35. Rossini A, Militi S, Sposi NM, Pelosi E, Testa U. Modulation by growth factors of the expression of interleukin 3 and granulocyte-macrophage colony-stimulating factor receptor common chain beta c. Leukemia & Lymphoma 2002;43(8):1645-1650.
  36. Rossini A, Militi S, Sposi NM, Pelosi E, Testa U. Modulation of growth factors of the expression of interleukin 3 and granulocyte-macrophage colony-stimulating factor receptor common chan beta c. Leukemia & Lymphoma 2002;43(8):1645-1650.
  37. Saulle E, Testa U, Zeuner A, Morsilli O, Rossini A, Sposi NM, Peschle C, Gabbianelli M. Upmodulation of ID2 correlates with an enhanced gamma-globin expression in adult BFU-E culture induced with kit ligand and dexamethasone [abstract]. Hematology journal 2002;3(Suppl 1):58.
  38. Sposi NM, Rossini A, Cianetti L, Saulle E, Pasquini L, Petrucci E, Morsilli O, Gabbianelli M, Testa U. Expression of NRAMP2 and ferroportin-1 during normal hemopoiesis [abstract]. Hematology journal 2002;3(Suppl 1):183.
  39. Sposi NM, Rossini A, Cianetti L, Saulle E, Petrucci E, Gabbianelli M, Peschle C, Testa U. Pattern od ferroportin-1 and Nramp2 gene expression in normal hematopoiesis. In: 6. International Symposium on Predictive Oncology & Intervention Strategies. Cancer Detection and Prevention. Abstracts; February 9-12, 2002; Paris. Paris: ISPO; 2002. p.S-75.
  40. Testa U. Proteins of iron metabolism. Boca Raton: CRC Press; 2002.
  41. Testa U. Recent developments in the understanding of iron metabolism. Hematology journal 2002;3(2):63-89.
  42. Coppola S, Feccia T, Narciso L, Bonci D, Conticello C, Testa U, De Maria R, Peschle C. Ectopic expression of KDR on TF1 progenitor cell line induces transient expression of endothelial markers and fas-mediated apoptosis [abstract]. Blood 2001;98(11 part 1):556a.
  43. Gabbianelli M, Massa A, Morsilli O, Saulle E, Sposi NM, Testa U, Peschle C. Reactivation of HbF synthesis in sigle cell adult BFU-E culture: synergistic effect of kit ligand and low dose dexamethasone [abstract]. Blood 2001;98(11 part 2):21b.
  44. Guerriero R, Mattia G, Testa U, Chelucci C, Macioce G, Casella I, Samoggia P, Peschle C, Hassan HJ. Stromal cell-derived factor 1alfa increases polyploidization of megakaryocytes generated by human hematopoietic progenitor cells. Blood 2001;97(9):2587-2595.
  45. Labbaye C, Quaranta MT, Pagliuca A, Militi S, Grignani F, Licht JD, Testa U, Peschle C. PLZF induces megakaryocytic differentiation and interact with GATA-1 protein and Tpo receptor promoter [abstract]. Blood 2001;98(11 part 2):127b.
  46. Pelosi E, Valtieri M, Sgadari C, Coppola S, Testa U, Peschle C. Post-natal CD34+KDR+ cells generate both hematopoietic and endothelial cells in minibulk culture [abstract]. Blood 2001;98(11 part 2):124b.
  47. Testa U, Torelli GF, Riccioni R, Onetti Muta A, Militi S, Annino L, Mariani G, Guarini A, Mandelli F, Peschle C, Foa R. Human acute leukemia with stem cell phenotype: multineage differentiation potential via cascade activation of growth factor receptors [abstract]. Blood 2001;98(11 part 2):196b.
  48. Valtieri M, Pelosi E, Botta R, Mueller R, Sgadari C, Coppola S, Masella B, Testa U, Rafii S, Peschle C. Identification of the hemoangioblast in post-natal CD34+KDR+cells [abstract]. Blood 2001;98(11 part 1):713a.
  49. Coccia EM, Stellacci E, Valtieri M, Masella B, Feccia T, Marziali G, Hiscott J, Testa U, Peschle C, Battistini A. Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation. Biochemical journal 2001;360(Pt 2):285-294.
  50. Matarrese P, Testa U, Cauda R, Vella S, Gambardella L, Malorni V. Expression of P-170 glycoprotein sensitizes lymphoblastoid CEM cells to mitochondria-mediated apoptosis. Biochemical journal 2001;355(Pt 3):587-595.
  51. Camagna A, Cedrone L, Carè A, Samoggia P, De Marco MC, Del Duca P, De Martinis C, Testa U. Polyclonal expansion of CD3+ /CD4+ /CD56+ large granular lymphocytes and auto immunity associated with dysregulation of Fas/FasL apoptotic pathway. British journal of haematology 2001;112(1):204-207.
  52. Testa U. Lo sviluppo di farmaci anti-tumorali: aspetti scientifici e normativi. In: Massotti M, Meneguz A. Obiettivi e interpretazione degli studi pre-clinici richiesti per avviare la sperimentazione clinica di fase I. Roma: Istituto Superiore di Sanità; 2001. (Rapporti ISTISAN 01/22). p.60-73.
  53. Gabbianelli M, Testa U, Massa A, Pelosi E, Sposi NM, Riccioni R, Lucchetti L, Peschle C. Hemoglobin switching in unicellular erythroid culture of sibling erythroid burst-forming units: kit ligand induces a dose-dependent fetal hemoglobin reactivation potentiated by sodium butyrate. Blood 2000;95(11):3555-3561.
  54. Militi S, Riccioni R, Parolini I, Sposi NM, Samoggia P, Pelosi E, Testa U, Peschle C. Expression of interleukin 3 and granulocyte-macrophage colony-stimulating factor receptor common chain betac, betaIT in normal haematopoiesis: lineage specificity and proliferation-independent induction. British journal of haematology 2000;111(2):441-451.
  55. Sposi NM, Cianetti L, Tritarelli E, Pelosi E, Militi S, Barberi T, Gabbianelli M, Saulle E, Kuhn LC, Peschle C, Testa U. Mechanisms of differential transferrin receptor expression in normal hematopoiesis. European journal of biochemistry 2000;267(23):6762-6774.
  56. Testa U. Mécanismes apoptotiques et controle de l'érythropoïèse normale et patologique. Hematologie 2000;6:449-461.
  57. Chelucci C, Casella I, Federico M, Testa U, Macioce G, Pelosi E, Guerriero R, Mariani G, Giampaolo A, Hassan HJ, Peschle C. Lineage-specific expression of human immunodeficiency virus (HIV) receptor/coreceptors in differentiating hematopoietic precursors: correlation with susceptibility to T- and M-tropic HIV and chemokine-mediated HIV resistance. Blood 1999;94(5):1590-1600.
  58. Coccia EM, Del Russo N, Stellacci E, Testa U, Marziali G, Battistini A. STAT1 activation during monocyte to macrophage maturation: role of adhesion molecules. International immunology 1999;11(7):1075-1083.
  59. De Maria R, Grignani F, Testa U, Valtieri M, Ziegler BL, Peschle C. Gene regulation in normal and leukemic progenitor/stem cells. Haematologica 1999;84(EAH-4 Edu.):8-10.
  60. De Maria R, Testa U, Luchetti L, Zeuner A, Stassi G, Pelosi E, Riccioni R, Felli N, Samoggia P, Peschle C. Apoptotic role of Fas/Fas ligand system in the regulation of erythropoiesis. Blood 1999;93(3):796-803.
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