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ISS : About Us : ISS Personnel : Pietro Alano 

Pietro Alano 
Senior Researcher

Telephone: +39 +39 06 4990 2617 - 2226
Viale Regina Elena 299
00161 - Roma (I)
pietro.alano@iss.it

Publications

  1. Lavazec C, Alano P. Uncovering the hideout of malaria sexual parasites. Blood 2014;123(7):954-955.
  2. D'Alessandro S, Silvestrini F, Dechering K, Corbett Y, Parapini S, Timmerman M, Galastri L, Nicoletta B, Sauerwein R, Alano P, Taramelli D. A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection. Journal of antimicrobial chemotherapy 2013;68(9):2048–2058.
  3. Tibúrcio M, Silvestrini F, Bertuccini L, Sander AF, Turner L, Lavstsen T, Alano P. Early gametocytes of the malaria parasite Plasmodium falciparum specifically remodel the adhesive properties of infected erythrocyte surface. Cellular microbiology 2013;15(4):647-659.
  4. Tibúrcio M, Niang M, Deplaine G, Perrot S, Bischoff E, Ndour PA, Silvestrini F, Khattab A, Milon G, David PH, Hardeman M, Vernick KD, Sauerwein RW, Preiser PR, Mercereau-Puijalon O, Buffet P, Alano P, Lavazec C. A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stages. Blood 2012;119(24):e172-e180.
  5. Lasonder E, Green JL, Camarda G, Talabani H, Holder AA, Langsley G, Alano P. The Plasmodium falciparum schizont phosphoproteome reveals extensive phosphatidylinositol and cAMP-protein kinase A signalling. Journal of proteome research 2012;11(11):5323-5337.
  6. Silvestrini F, Tibúrcio M, Bertuccini L, Alano P. Differential adhesive properties of sequestered asexual and sexual stages of Plasmodium falciparum on human endothelial cells are tissue independent. PLoS One 2012;7(2):e31567.
  7. Sannella AR, Olivieri A, Bertuccini L, Ferrè F, Severini C, Pace T, Alano P. Specific tagging of the egress-related osmiophilic bodies in the gametocytes of Plasmodium falciparum. Malaria journal 2012;11:88.
  8. Silvestrini F, Lasonder E, Olivieri A, Camarda G, Schaijk BV, Sanchez M, Younis Younis S, Sauerwein R, Alano P. Protein export marks the early phase of gametocytogenesis of the human malaria parasite Plasmodium falciparum. Molecular and cellular proteomics 2010;9(7):1437-1448.
  9. Camarda G, Bertuccini L, Singh SK, Salzano AM, Lanfrancotti A, Olivieri A, Scaloni A, Sharma A, Alano P. Regulated oligomerisation and molecular interactions of the early gametocyte protein Pfg27 in Plasmodium falciparum sexual differentiation. International journal for parasitology 2010;40(6):663-673.
  10. Ponzi M, Sidén-Kiamos I, Bertuccini L, Currà C, Kroeze H, Camarda G, Pace T, Franke-Fayard B, Laurentino EC, Louis C, Waters AP, Janse CJ, Alano P. Egress of Plasmodium berghei gametes from their host erythrocyte is mediated by the MDV-1/PEG3 protein. Cellular microbiology 2009;11(8):1272-1288.
  11. Olivieri A, Camarda G, Bertuccini L, van de Vegte-Bolmer M, Luty AJF, Sauerwein R, Alano P. The Plasmodium falciparum protein Pfg27 is dispensable for gametocyte and gamete production, but contributes to cell integrity during gametocytogenesis. Molecular microbiology 2009;73(2):180-193.
  12. Bultrini E, Brick K, Mukherjee S, Zhang Y, Silvestrini F, Alano P, Pizzi E. Revisiting the Plasmodium falciparum RIFIN family: from comparative genomics to 3D-model prediction. BMC genomics 2009;10:445.
  13. Doerig C, Baker D, Billker O, Blackman MJ, Chitnis C, Dhar SK, Heussler V, Holder AA, Kocken C, Krishna S, Langsley G, Lasonder E, Menard R, Meissner M, Pradel G, Ranford-Cartwright LC, Sharma A, Sharma P, Tardieux I, Tatu U, Alano P. Signalling in malaria parasites. The MALSIG consortium. Parasite 2009;16(3):169-182.
  14. Ponzi M, Su X, Alano P, Pizzi E, Superti F, Bertuccini L, Waters AP, Janse CJ, Sidén-Kiamos I. Studio e validazione di processi molecolari poco studiati in plasmodio come potenziali bersagli per il disegno di nuove strategie farmacologiche. In: Garaci E, D'Addazio C, Giuliano F, ed. Programma di collaborazione ISS-NIH: relazioni conclusive dei progetti. ISS-NIH Collaborative Programme: final report of the projects. Edizione bilingue. Bilingual edition. Roma: Istituto Superiore di Sanità; 2009. (Rapporti ISTISAN 09/05). p.207-208.
  15. Ponzi M, Su X, Alano P, Pizzi E, Superti F, Bertuccini L, Waters AP, Janse CJ, Sidén-Kiamos I. Study and validation of underexplored molecular processes in plasmodium as potential drug targets for new intervention strategies. In: Garaci E, D'Addazio C, Giuliano F, ed. Programma di collaborazione ISS-NIH: relazioni conclusive dei progetti. ISS-NIH Collaborative Programme: final report of the projects. Edizione bilingue. Bilingual edition. Roma: Istituto Superiore di Sanità; 2009. (Rapporti ISTISAN 09/05). p.431-432.
  16. de Koning-Ward T, Olivieri A, Bertuccini L, Hood A, Silvestrini F, Charvalias K, Berzosa Dìaz P, Camarda G, McElwain T, Papenfuss T, Healer J, Baldassarri L, Crabb BS, Alano P, Ranford-Cartwright LC. The role of osmiophilic bodies and Pfg377 expression in female gametocyte emergence and mosquito infectivity in the human malaria parasite Plasmodium falciparum. Molecular microbiology 2008;67(2):278-290.
  17. Olivieri A, Silvestrini F, Sanchez M, Alano P. A 140-bp AT-rich sequence mediates positive and negative transcriptional control of a Plasmodium falciparum developmentally regulated promoter. International journal for parasitology 2008;38(3-4):299-312.
  18. Merckx A, Nivez MP, Bouyer G, Alano P, Langsley G, Deitsch K, Thomas S, Doerig C, Egée S. Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductance . PLoS pathogens 2007;4(2):e19.
  19. Alano P. Plasmodium falciparum gametocytes: still many secrets of a hidden life. Molecular microbiology 2007;66(2):291-302.
  20. Lanfrancotti A, Bertuccini L, Silvestrini F, Alano P. Plasmodium falciparum: mRNA co-expression and protein co-localisation of two gene products upregulated in early gametocytes. Experimental parasitology 2007;116(4):497-503.
  21. Ponzi M, Su X, Alano P, Pizzi E, Superti F, Bertuccini L, Waters AP, Janse CJ. Study and validation of underexplored molecular processes in plasmodium as potential drug targets for new intervention strategies. In: Garaci E, D'Addazio C, Giuliano F, ed. ISS/NIH Collaborative Programme 2006 Progress report meeting. Istituto Superiore di Sanità. Rome, July 4-6, 2006. Proceedings. Roma: Istituto Superiore di Sanità; 2006. (Rapporti ISTISAN 06/50). p.256-260.
  22. Dorin D, Semblat JP, Poullet P, Alano P, Goldring J, Whittle C, Patterson S, Chakrabarti D, Doerig C. PfPK7, an atypical MEK-related protein kinase, reflects the absence of classical three-component MAPK pathways in the human malaria parasite Plasmodium falciparum. Molecular microbiology 2005;55(1):184-196.
  23. Chandra BR, Olivieri A, Silvestrini F, Alano P, Sharma A. Biochemical characterization of the two nucleosome assembly proteins from Plasmodium falciparum. Molecular and biochemical parasitology 2005;142(2):237-247.
  24. Silvestrini F, Bozdech Z, Lanfrancotti A, Di Giulio E, Bultrini E, Picci L, De Risi JL, Pizzi E, Alano P. Genome-wide identification of genes upregulated at the onset of gametocytogenesis in Plasmodium falciparum. Molecular and biochemical parasitology 2005;143(1):100-110.
  25. Alano P, Billker O. Gametocytes and gametes. In: Molecular approaches to malaria Washington: ASM Press; 2005. p.191-219.
  26. Alano P. Molecular approaches to monitor parasite genetic complexity in the transmission of Plasmodium falciparum malaria. Parassitologia 2005;47:199-203.
  27. Di Girolamo F, Raggi C, Bultrini E, Lanfrancotti A, Silvestrini F, Sargiacomo M, Birago C, Pizzi E, Alano P, Ponzi M. Functional genomics, new tools in malaria research. Annali dell'Istituto Superiore di Sanità 2005;41(04):469-477.
  28. Droucheau E, Primot A, Thomas V, Mattei D, Knockaert M, Richardson C, Sallicandro P, Alano P, Jafarshad A, Baratte B, Kunick C, Parzy D, Pearl L, Doerig C, Meijer L. Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors. Biochimica et biophysica acta-proteins and proteomics 2004;1697(1-2):181-196.
  29. Merckx A, Le Roch K, Nivez MP, Dorin D, Alano P, Gutierrez G, Nebreda A, Goldring J, Whittle C, Patterson S, Chakrabarti D, Doerig C. Identification and initial characterization of three novel cyclin-related proteins of the human malaria parasite Plasmodium falciparum. Journal of biological chemistry 2003;278(41):39839-39850.
  30. Birago C, Albanesi V, Silvestrini F, Picci L, Pizzi E, Alano P, Pace T, Ponzi M. A gene-family encoding small exported proteins is conserved across Plasmodium genus. Molecular and biochemical parasitology 2003;126(2):209-218.
  31. Silvestrini F, Bozdech Z, De Risi JL, Alano P. A genome-wide approach to the study of Plasmodium falciparum gene expression associated to early events in sexual differentiation. In: 13. Molecular Parasitology Meeting (MPM). Abstracts; September 22-26, 2002; Woods Hole. 2002. p.229A.
  32. Dorin D, Le Roch K, Sallicandro P, Alano P, Parzy D, Poullet P, Meijer L, Doerig C. Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum. European journal of biochemistry 2001;268(9):2600-2608.
  33. Menegon M, Severini C, Sannella AR, Paglia MG, Sangaré D, Abdel-Wahab A, Abdel-Muhsin A, Hamza B, Walliker D, Alano P. Genotyping of Plasmodium falciparum gametocytes by reverse transcriptase polymerase chain reaction. Molecular and biochemical parasitology 2000;111(1):153-161.
  34. Sallicandro P, Paglia MG, Hashim SO, Silvestrini F, Picci L, Gentile M, Mulaa F, Alano P. Repetitive sequences upstream of the pfg27/25 gene determine polymorphism in laboratory and natural lines of Plasmodium falciparum. Molecular and biochemical parasitology 2000;110(2):247-257.
  35. Silvestrini F, Alano P, Williams JL. Commitment to the production of male and female gametocytes in the human malaria parasite Plasmodium falciparum. Parasitology 2000;121(Pt 5):465-471.
  36. Alano P, Birago C, Picci L, Ponzi M, Sallicandro P, Scotti R, Silvestrini F. Genome plasticity and sexual differentiation in Plasmodium. Parassitologia 1999;41(1-3):149-151.
  37. Dorin D, Alano P, Boccaccio I, Cicéron L, Doerig C, Sulpice R, Parzy D, Doerig C. An atypical mitogen-activated protein kinase (MAPK) homologue expressed in gametocytes of the human malaria parasite Plasmodium falciparum. Journal of biological chemistry 1999;274(42):29912-29920.
  38. Putignani L, Sallicandro P, Alano P, Abrahamsen MS, Crisanti A, Spano F. Chromosome mapping in Cryptosporidium parvum and establishment of a long-range restriction map for chromosome VI. FEMS microbiology letters 1999;175:231-238.
  39. Severini C, Silvestrini F, Sannella AR, Barca S, Gradoni L, Alano P. The production of the osmiophilic body protein Pfg377 is associated with stage of maturation and sex in Plasmodium falciparum gametocytes. Molecular and biochemical parasitology 1999;100(2):247-252.
  40. Alano P, Silvestrini F, Sallicandro P. Molecular studies on the pathway of sexual differentiation in the human malaria parasite Plasmodium falciparum. South African journal of science 1998;94:298.
  41. Alano P, Silvestrini F, Roca L. Structure and polymorphism of the upstream region of the pfg27/25 gene, transcriptionally regulated in gametocytogenesis of Plasmodium falciparum. Molecular and biochemical parasitology 1996;79(2):207-217.
  42. Alano P, Read D, Bruce M, Aikawa M, Kaido T, Tegoshi T, Bhatti S, Smith DK, Luo C, Hansra S, Carter R, Elliott JF. COS cell expression clonng of Pfg377, a Plasmodium falciparum gametocyte antigen associated with osmiophilic bodies. Molecular and biochemical parasitology 1995;74(2):143-156.
  43. Alano P, Roca L, Smith D, Read D, Carter R, Day K. Plasmodium falciparum: parasites defective in early stages of gametocytogenesis. Experimental parasitology 1995;81(2):227-235.
  44. Sultan AA, Richardson WA, Alano P, Arnot DE, Doerig C. Cloning and characterisation of a Plasmodium falciparum homologue of the Ran/TC4 signal transducing GTPase involved in cell cycle control. Molecular and biochemical parasitology 1994;65(2):331-338.
  45. Ponzi M, Alano P, Scotti R, Roca L. Chromosomal polymorphism and sexual differentiation in plasmodium. Parassitologia 1993;35(Suppl):87-89.
  46. White JH, Kilbey BJ, De Vries E, Goman M, Alano P, Cheesman S, McAleese S, Ridley RG. The gene encoding DNA polymerase a from Plasmodium falciparum. Nucleic acids research 1993;21(16):3643-3646.
  47. Scherf A, Carter R, Petersen C, Alano P, Nelson R, Aikawa M, Mattei D, Pereira da Silva L, Leech J. Gene inactivation of Pf11-1 of Plasmodium falciparum by chromosome breakage and healing: identification of a gametocyte-specific protein with a potential role in gametogenesis. EMBO journal 1992;11(6):2293-2701.
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