Istituto Superiore di Sanità

 

Curriculum professionale

Note Biografiche

Nato a Roma il 14/2/1959
Laurea in Scienze Biologiche 110/110 con lode Universita' di Roma, La Sapienza.

Incarichi

Professore a contratto di Biofisica, Universita' di Roma 'La Sapienza'
Membro Collegio Docenti, Dottorato di Ricerca in Biofisica, Universita' di Roma, La Sapienza.
Visiting Professor, Universita' di Chicago, Biofisica
Visiting Professor, Istituto di Bioinformatica, Singapore
Visiting Professor, Universita' Keio, Tsuruoka, Giappone
Membro Editorial Board 'Current Bioinformatics'
Membro Editorial Board 'Systems and Synthetic Biology'

Attività di Ricerca

Analisi dei dati in Biologia, con particolare riguardo all'applicazione della statistica multivariata e metodi nonlineari (analisi delle ricorrenze, misure di complessita') allo studio di segnali biologici e delle sequenze proteiche. Bioinformatica e Biofisica di sistemi reticolari.

Progetti di ricerca

Progetto Intramurale Bioinformatica
Progetto NSF
0240230 Nonlinear Signal Analysis Approach to Protein Structure / Dynamics
'Different Fields Collaboration Grant' JSF_CREST Ministero della Ricerca , Giappone

Incarichi Istituzionali

Membro gruppo OECD tossicogenomica
Esaminatore concorso ISS posto di ricercatore in Bioinformatica
Valutatore EU: FP6-2003-NEST-A; FP6-2003-NEST-B ; FP6-NEST-PATH-SP1. April – July, 2004.
Valutatore EU , Sixth Framework Programme: FP6-2005-NEST-A; FP6-2005-NEST-B ; FP6-NEST-PATH-SP1. April 2006.

Membership

Societa' Italiana di Biofisica Pura e Applicata
Societa' Italiana Caos e Complessita'

Pubblicazioni

1. Bianciardi M, Sirabella P, Hagberg GE, Giuliani A, Zbilut JP, Colosimo A. Model-free analysis of brain fMRI data by recurrence quantification. NeuroImage 2007;37/2). p.489-503.
   
2. Mairesse J, Viltart O, Salomé N, Giuliani A, Catalani A, Casolini P, Morley Fletcher S, Nicoletti F, Maccari S. Prenatal stress alters the negative correlation between neuronal activation in limbic regions and behavioral responses in rats exposed to high and low anxiogenic environments. Psychoneuroendocrinology 2007;32/7). p.765-776.
   
3. Zbilut JP, Chua GH, Krishnan A, Bossa C, Rother K, Webber CL, Giuliani A. A topologically related singularity suggests a maximum preferred size for protein domains. Proteins-structure function and bioinformatics 2007;66/3). p.621-629.
   
4. Palumbo MC, Colosimo A, Giuliani A, Farina L. Essentiality is an emergent property of metabolic network wiring. FEBS letters 2007;581/13). p.2485-2489.
   
5. Casorelli I, Tenedini E, Tagliafico E, Blasi MF, Giuliani A, Crescenzi M, Pelosi E, Testa U, Peschle C, Mele L, Diverio D, Breccia M, Lo-Coco F, Ferrari S, Bignami M. Identification of a molecular signature for leukemic promyelocytes and their normal counterparts: focus on DNA repair genes. Leukemia 2006;20/11). p.978-1988.
   
6. Tun K, Dhar PK, Palumbo MC, Giuliani A. Metabolic pathways variability and sequence/networks comparisons. BMC bioinformatics 2006;7p.24.
   
7. Valerio MC, Colosimo A, Conti F, Giuliani A, Grottesi A, Manetti C, Zbilut JP. Early events in protein aggregation: molecular flexibility and hydrophobicity/charge interaction in amyloid peptides as studied by molecular dynamics simulations. Proteins-structure function and genetics 2005;58/1). p.110-118.
   
8. Palumbo MC, Colosimo A, Giuliani A, Farina L. Functional essentiality from topology features in metabolic networks: a case study in yeast. FEBS letters 2005;579/21). p.4642-4646.
   
9. Colafranceschi M, Colosimo A, Zbilut JP, Uversky VN, Giuliani A. Structure-related statistical singularities along protein sequences: a correlation study. Journal of chemical information and computer science 2005;45/1). p.183-189.
   
10. Zbilut JP, Giuliani A, Colosimo A, Mitchell JH, Colafranceschi M, Marwan N, Webber CL, Uversky VN. Charge and hydrophobicity patterning along the sequence predicts the folding mechanism and aggregation of proteins: a computational approach. Journal of proteome research 2004;3/6). p.1243-1253.
    
11. Porrello A, Soddu S, Zbilut JP, Crescenzi M, Giuliani A. Discrimination of single amino acid mutations of the p53 protein by means of deterministic singularities of recurrence quantification analysis. Proteins-structure function and bioinformatics 2004;55/3). p.743-755.
    
12. Casorelli I, Blasi MF, Giuliani A, Bignami M. Control of genetic stability and global cellular responses to DNA damage. In: Parisi V, DeFonzo V, Aluffi-Pentini F, ed. Dynamical genetics Kerala: Trivandrum; 2004. p. 121-131.
    
13. Giuliani A, Zbilut JP. NL 3213 Algorithmic complexity. In: Scott A, ed. New York: Taylor and Francis Routledge; 2004. .
    
14. Benigni R, Giuliani A. Putting the predictive toxicology challenge into perspective: reflections on the results. Bioinformatics 2003;19/10). p.1194-1200.
    
15. Zbilut JP, Colosimo A, Conti F, Colafranceschi M, Manetti C, Valerio MC, Webber CL, Giuliani A. Protein aggregation/folding: the role of deterministic singularities of sequence hydrophobicity as determined by nonlinear signal analysis of acylphosphatase and A-beta(1-40). Biophysical journal 2003;85/6). p.3544-3557.
    
16. Giuliani A, Benigni R, Colafranceschi M, Chandrashekar I, Cowsik SM. Large contact surface interactions between proteins detected by time series analysis methods: case study on C-Phycocyanins. Proteins-structure function and genetics 2003;51/2). p.299-310.
    
17. Cotta Ramusino M, Benigni R, Passerini L, Giuliani A. Looking for an unambiguous geometrical definition of organic series from 3-D molecular similarity indices. Journal of chemical information and computer science 2003;43/1). p.248-254.
    
18. Zimatore G, Giuliani A, Hatzopoulos S, Martini A, Colosimo A. Otoacoustic emissions at different click intensities: invariant and subject dependent features. Journal of applied physiology 2003;95/6). p.2299-2305.
    
19. Lligona Trulla L, Zbilut JP, Giuliani A. Putting relative complexity estimates to work: a simple and general statistical methodology. Physica A: Statistical mechanics and its applications 2003;319p.591-600.
    
20. Benigni R, Giuliani A, Gruska A, Franke R. QSARs for the mutagenicity and carcinogenicity of the aromatic amines. In: Quantitative structure-activity relationship (QSAR). Models of mutagens and carcinogens Boca Raton: CRC Press; 2003. p. 125-144.
    
21. Giuliani A, Benigni R, Zbilut JP, Webber CL, Sirabella P, Colosimo A. Nonlinear signal analysis methods in the elucidation of protein sequence-structure relationships. Chemical reviews 2002;102/5). p.1471-1491.
    
22. Giuliani A, Tomasi M. Recurrence quantification analysis reveals interaction partners in paramyxoviridae envelope envelope glycoproteins. Proteins-structure function and genetics 2002;46/2). p.171-176.
    
23. Zimatore G, Hatzopoulos S, Giuliani A, Martini A, Colosimo A. Comparison of transient otoacoustic emission responses from neonatal and adult ears. Journal of applied physiology 2002;92/6). p.2521-2528.
    
24. Zbilut JP, Sirabella P, Giuliani A, Manetti C, Colosimo A, Webber CLJ. Review of nonlinear analysis of proteins through recurrence quantification. Cell biochemistry and biophysics 2002;36/1). p.67-87.
    
25. Colussi C, Fiumicino S, Giuliani A, Rosini S, Musiani P, Macrì C, Potten CS, Crescenzi M, Bignami M. 1,2-Dimethylhydrazine-induced colon carcinoma and lymphoma in msh2(-/-) mice. Journal of the National cancer institute 2001;93/20). p.1534-1540.
    
26. Franke R, Gruska A, Giuliani A, Benigni R. Prediction of rodent carcinogenicity of aromatic amines: a quantitative structure-activity relationships model. Carcinogenesis 2001;22/9). p.1561-1571.
    
27. Webber CL, Giuliani A, Zbilut JP, Colosimo A. Elucidating protein secondary structures using alpha-carbon recurrence quantifications. Proteins-structure function and genetics 2001;44/3). p.292-303.
    
28. Crescenzi M, Giuliani A. The main biological determinants of tumor line taxonomy elucidated by a principal component analysis of microarray data. FEBS letters 2001;507/1). p.114-118.
    
29. Benigni R, Giaimo R, Matranga D, Giuliani A. The sex difference in tumor incidence is related to the female condition: models for Europe and Italy. Environmental health perspectives 2001;109/7). p.705-709.
    
30. Benigni R, Giuliani A, Passerini L. Infrared spectra as chemical descriptors for QSAR models. Journal of chemical information and computer science 2001;41/3). p.727-730.
    
31. Sirabella P, Giuliani A, Colosimo A, Dippner WJ. Breaking down the climate effects on cod recruitment by principal component analysis and canonical correlation. Marine ecology progress series 2001;216p.213-222.
    
32. Portner A, Berdal B, Blust R, Brix O, Colosimo A, De Wachter B, Giuliani A, Johansen K, Fischer T, Knust R, Lanning G, Naevdal G, Nedenes A, Nyhammer G, Sartoris FJ, Serendero I, Sirabella P, Thorkildsen S, Zakhartsev M. Climate induced temperature effects on growth performance, fecundity and recruitment in marine fish: developing a hypothesis for cause and effect relationships in Atlantic cod (Gadus morhua) and common eelpout (Zoarces viviparus). Continental shelf research 2001;21p.1975-1997.
    
33. Manetti C, Giuliani A, Ceruso M, Webber CL, Zbilut JP. Recurrence analysis of hydration effects on nonlinear protein dynamics: multiplicative scaling and additive processes. Physics letters A 2001;281/5-6). p.317-323.
    
34. Giuliani A, Colafranceschi M, Webber CL, Zbilut JP. A complexity score derived from principal components analysis of nonlinear order measures. Physica A: Statistical mechanics and its applications 2001;301/1-4). p.567-588.
    
35. Benigni R, Giuliani A, Franke R, Gruska A. Quantitative structure-activity relationships of mutagenic and carcinogenic aromatic amines. Chemical reviews 2000;100/10). p.3697-3714.
    
36. Giuliani A, Benigni R, Sirabella P, Zbilut JP, Colosimo A. Nonlinear methods in the analysis of protein sequences: a case study in rubredoxins. Biophysical journal 2000;78/1). p.136-148.
    
37. Benigni R, Cotta Ramusino M, Gallo G, Giorgi F, Giuliani A, Varì MR. Deriving a quantitative chirality measure from molecular similarity indices. Journal of medicinal chemistry 2000;43/20). p.3699-3703.
    
38. Giuliani A, Sirabella P, Benigni R, Colosimo A. Mapping protein sequence spaces by recurrence quantification analysis: a case study on chimeric structures. Protein engineering 2000;13/10). p.671-678.
    
39. Zbilut JP, Webber CL, Colosimo A, Giuliani A. The role of hydrophobicity patterns in prion folding as revealed by recurrence quantification analysis of primary structure. Protein engineering 2000;13/2). p.101-106.
    
40. Zimatore G, Giuliani A, Parlopiano C, Grisanti G, Colosimo A. Revealing deterministic structures in click-evoked otoacoustic emissions. Journal of applied physiology 2000;88p.1431-1437.
    
41. Benigni R, Giaimo R, Matranga D, Giuliani A. The cultural heritage shapes the pattern of tumour profiles in Europe: a correlation study. Journal of epidemiology and community health 2000;54/4). p.262-268.
    
42. Zbilut JP, Giuliani A, Webber CL. Recurrence quantification analysis as an empirical test to distinguish relatively short deterministic versus random number. Physics letters A 2000;267/2-3). p.174-178.
    
43. Benigni R, Giuliani A. Tumor profiles and incidence in Europe: robustness of spatial patterns of correlation, and their relation with allele frequencies of the AB0 blood group system. Journal of environmental science and health Part C-Environmental carcinogenesis and ecotoxicology reviews 2000;18/1). p.15-50.
    
44. Benigni R, Gallo G, Giorgi F, Giuliani A. On the equivalence between different descriptions of molecules: value for computational approaches. Journal of chemical information and computer science 1999;39/3). p.575-578.
    
45. Benigni R, Giuliani A. Tumor profiles and carcinogenic potency in rodents and humans: value for cancer risk assessment. Journal of environmental science and health Part C-Environmental carcinogenesis and ecotoxicology reviews 1999;c17/1). p.45-67.
    
46. Benigni R, Passerini L, Livingstone DJ, Johnson MA, Giuliani A. Infrared spectra information and their correlation with QSAR descriptors. Journal of chemical information and computer science 1999;39/3). p.558-562.
    
47. Manetti C, Ceruso M, Giuliani A, Webber CL, Zbilut JP. Recurrence quantification analysis as a tool for characterization of molecular dynamics simulations. Physical review. E, Statistical, nonlinear, and soft matter physics 1999;59/1). p.992-998.
    
48. Manetti C, Ceruso M, Giuliani A, Webber CL, Zbilut JP. Recurrence quantification analysis in molecular dynamics. Annals of the New York Academy of Sciences 1999;879p.258-266.
    
49. Giuliani A, Colosimo A, Benigni R, Zbilut JP. On the constructive role of noise in spatial systems. Physics letters A 1998;247/1-2). p.47-52.
    
50. Giuliani A, Piccirillo G, Marigliano V, Colosimo A. A nonlinear explanation for aging-induced changes in heartbeat dynamics. American journal of physiology-cell physiology 1998;275/4 Pt 2). p.455-61.
    
51. Giuliani A, Piccirillo G, Marigliano V, Colosimo A. A nonlinear explanation of aging-induced changes in heartbeat dynamics. American journal of physiology 1998;275/4 Pt 2). p.H1455-H1461.
    
52. Giuliani A, Zbilut JP. The relevance of physical and mathematical modes of thought on complex systems behavior in biological systems. Complexity 1998;3/5). p.23-24.
    
53. Zbilut JP, Giuliani A, Webber CL, Colosimo A. Recurrence quantification analysis in structure-function relationship of proteins: an overview of a general methodology applied to the case of TEM-1 beta-lactamase. Protein engineering 1998;11/2). p.87-93.
    
54. Zbilut JP, Giuliani A, Webber CL. Detecting deterministic signals in exceptionally noisy environments using cross-recurrence quantification. Physics letters A 1998;246p.122-128.
    
55. Zbilut JP, Giuliani A, Webber CL. Recurrence quantification analysis and principal components in the detection of short complex signals. Physics letters A 1998;237p.131-135.
    
56. Benigni R, Giuliani A. Quantitative structure-activity relationship (QSAR) studies of mutagens and carcinogens. Medicinal research reviews 1996;16/3). p.267-284.
    
57. Benigni R, Giuliani A. Quantitative modeling and biology: the multivariate approach. American journal of physiology 1994;266/5 Pt2). p.R1697-R1704.
    
58. Benigni R, Giuliani A. Analysis of distance matrices for studying data structures and separating classes. Quantitative structure-activity relationships 1993;12p.397-401.
    
59. Benigni R, Cotta Ramusino M, Andreoli C, Giuliani A. Electrophilicity as measured by Ke: molecular determinants, relationship with other physical-chemical and quantum mechanical parameters, and ability to predict rodent carcinogenicity. Carcinogenesis 1992;13/4). p.547-553.
    
60. Benigni R, Giuliani A. Mathematical models for exploring different aspects of genotoxicity and carcinogenicity databases. Environmental health perspectives 1991;/96). p.81-84.
    

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