Chronic diseases and healthy aging

TOPIC

Chronic diseases and aging

Chronic diseases and healthly aging

Chronic diseases (or non-communicable diseases) afflict about 24 million people in Italy. These conditions have an important impact on the quality and life expectancy of the population. These diseases affect all stages of life, although the most frequently affected segments of the population are the elderly (over 85% of people over 75 years of age suffer from chronic diseases) and women, especially after the age of 55.

It is therefore important to improve knowledge on the mechanisms and risk factors that lead to the development of chronic diseases, as well as on the possible strategies and programs for the prevention and treatment of these conditions in order to guarantee a healthy aging of the population.

In this area, the activities of the Istituto Superiore di Sanità (ISS, the National Institute of Health in Italy) develop on several fronts; from the study of risk factors for chronic diseases through surveys on the general population, in age of development, adult and elderly, to the identification of new biomarkers for early diagnosis and treatment. In addition, the ISS studies the efficacy and safety of new biomedical technologies for the treatment of cardiovascular diseases, as well as monitor autoimmune and endocrine-metabolic diseases, such as diabetes mellitus, thyroid diseases and growth hormone deficiency. The ISS is also engaged in strategies and models of assistance for people with chronic diseases and on the study of the processes that lead to healthy aging, with particular attention to epidemiological aspects and to the evaluation, recovery and maintenance of motor and physical function and sensorial of the elderly. Finally, a workspace is also dedicated to Health Literacy, and to the creation of a system for sharing and standardizing indicators of the health status of the European population and in areas at risk.



Back Sovrappeso, dimagrimento, danno e riparazione del danno al DNA

 

Che relazione c’è tra eccesso ponderale e danno del DNA? Cosa succede ai meccanismi normalmente deputati alla riparazione del danno al DNA quando c’è una situazione di sovrappeso o di obesità? E cosa cambia dopo un calo ponderale? Il Registro Nazionale Gemelli, in collaborazione con il dipartimento Ambiente e Salute dell’Istituto superiore di sanità e con il dipartimento di Medicina dei Sistemi dell’Università di Roma Tor Vergata, sta studiando 16 coppie di gemelli monozigoti composte da un gemello normopeso e l’altro in sovrappeso. Si stanno indagando il danno al DNA e le proteine deputate alla sua riparazione, i profili metabolico, lipidico e infiammatorio, lo stress ossidativo e il microbioma prima e dopo il dimagramento del gemello sovrappeso a seguito di una dieta ipocalorica di alcuni mesi. Studiare due gemelli geneticamente identici ci permette di analizzare gli effetti della differenza di peso, indipendentemente dall'influenza del patrimonio genetico ereditario. Accanto alle coppie di gemelli, stiamo studiando anche 36 pazienti obesi – non gemelli - che si sottopongono a chirurgia bariatrica per perdere peso.

 

Per info
Lorenza Nisticò, Istituto Superiore di Sanità
Viale Regina Elena, 299- 00161 Roma
Email: registro.nazionale.gemelli@iss.it


Dipartimenti/Centri/Servizi

Center of reference for behavioural sciences and mental health

Topics

Chronic diseases and aging Prevention and health promotion Obesity Mental health Psychological well-being and quality of life Tumors Prevention and identification of cancer risk factors