Rapporto ISS COVID-19 n. 29/2020 English version - Interim guidance on Kawasaki disease and acute multisystem inflammatory syndrome in children and adolescents in the current emergency scenario of SARS-CoV-2 infection. Version of May 21, 2020
Rapporti ISS COVID-19 in English
Istituto Superiore di Sanità
Interim guidance on Kawasaki disease and acute multisystem inflammatory syndrome in children and adolescents in the current emergency scenario of SARS-CoV-2 infection. Version of May 21, 2020.
ISS COVID-19 Rare Diseases Working Group
2020, 14 p. Rapporto ISS COVID-19 n. 29/2020 - English version
The available scientific evidence indicates that the clinical course of SARS-CoV-2 infection that occurs in pediatric patients has very low lethality rates (0.06% in the age group 0-15 years). However, recent European and US publications describe an acute multisystem inflammatory syndrome in children and adolescents, associated with positivity for SARS-CoV-2 or to the presence of antibodies antiSARS-CoV-2, the precise classification of which is currently in process. This syndrome seems to share some clinical features with KD, such as an aberrant inflammatory response and some therapeutic options (immunoglobulins, steroids, anti-cytokine drugs). The syndrome, however, could be distinguished from KD by other peculiarities, represented by the age of the affected subjects, severe multisystemic involvement, prevalent myocardial and / or gastrointestinal involvement. The document highlights that, at the moment, even in the absence of a European shared case definition, a correlation between SARS-CoV-2 infection and the onset of the syndrome is plausible, even if there is limited evidence of the causal link. It also stresses the absence of strong epidemiological evidence of an increased incidence of KD, as well as the absence of increased risk of disease recurrence and the absence of increased susceptibility to SARS-CoV-2 infection in patients with previous KD during the COVID-19 pandemic
Pubblicato il 03/06/2020