What is already known about this topic?

On December 16, 2021, the National Football League (NFL) updated its test-to-release from COVID-19 isolation protocols in response to increasing COVID-19 cases and predominance of the SARS-CoV-2 Omicron variant.

What is added by this report?

Among 173 vaccinated adults with COVID-19 undergoing serial reverse transcription–polymerase chain reaction (RT-PCR) testing during Omicron predominance, 46% received a negative or high cycle threshold RT-PCR test result on or before day 6 postdiagnosis.

What are the implications for public health practice?

Although a positive RT-PCR test result does not necessarily indicate infectiousness, these data indicate that persons with COVID-19 should continue to take precautions, including correct and consistent mask use, for a full 10 days after symptom onset or after initial positive test result if they are asymptomatic.

Entire content available on: https://www.cdc.gov/mmwr/volumes/71/wr/mm7108a4.htm