Interim Analysis of Acute Hepatitis of Unknown Etiology in Children Aged 10 Years — United States, October 2021–June 2022 | MMWR - ISS-G20 Laboratorium Repository

What is already known about this topic?

During October 2021–February 2022, a cluster of children with hepatitis of unknown etiology and adenovirus infection was identified in the United States. On April 21, after reports of similar cases in other countries, CDC advised clinicians to report patients aged <10 years with hepatitis of unknown etiology to public health authorities.

What is added by this report?

During October 1, 2021–June 15, 2022, a total of 296 U.S. pediatric patients received a diagnosis of hepatitis of unknown etiology, with adenovirus detected among 45%. Preliminary analyses have not identified common exposures (e.g., travel or toxicants).

What are the implications for public health practice?

The investigation is ongoing; further clinical data are needed to understand the cause of these cases and to assess the potential association with adenovirus.

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