Line probe assays for detection of drug-resistant tuberculosis: interpretation and reporting manual for laboratory staff and clinicians - ISS-G20 Laboratorium Repository

This document was developed to provide practical guidance on interpretation of the most commonly used first- and second-line line probe assays (LPAs). In this updated manual, the interpretation of mutations identified by the assays has been revised to align with the WHO catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance. It also presents the latest changes in instructions for use of the assays. In addition, the manual provides support for staff at national and regional TB reference laboratories in understanding and managing any discrepancies between phenotypic and genotypic drug susceptibility testing.

Entire content available on:  https://www.who.int/publications-detail-redirect/9789240046665