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Istituto Superiore di Sanità
About Us
Mission
Departments
National centres and Reference centres
Technical-scientific Services
History
Organization
Single guarantee committee
Regulations
ISS staff
Topics
Nutrition and food safety
Climate, environment and health
Dependencies
Medicines, vaccines and advanced therapies
Fertility
Gender and health
Clinical governance, National guidelines system (SNLG) and HTA
Chronic diseases and aging
Infectious diseases, HIV
Neurological diseases
Rare diseases
Prevention and health promotion
Radiation protection
Women's, children's and adolescents' health
Global health and health inequalities
Mental health
Veterinary public health
Chemical substances and health protection
Innovative technologies for health and telemedicine
Tumors
Activities
Databases
International collaborations
National Ethics Committee
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ISS-G20 Laboratorium
Reference laboratories
Guidelines - SNLG
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Servizio Civile Universale
Phase 1 clinical trials
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21 Hydroxylase Deficiency
Web Content Article
Adrenal glands are organs that produce the hormones cortisol, aldosterone, and androgens (delta4-androstenedione and dehydroepiandrosterone). Under certain conditions, the adrenal enzymes...
Infointersex Project:
Variations of Sex Characteristics/Differences of Sex Developmen
Turner Syndrome
Web Content Article
Turner syndrome is a congenital genetic syndrome caused by a numerical or structural alteration of the X sex chromosome. This syndrome occurs in approximately 1 in 2000/2500 live births, although...
Infointersex Project:
Variations of Sex Characteristics/Differences of Sex Developmen
Mixed Gonadal Dysgenesis
Web Content Article
Gonad is the generic term used to indicate the organs that produce sperm and egg cells, i.e., the testicles and the ovaries, respectively. These organs also produce sex hormones (testosterone,...
Infointersex Project:
Variations of Sex Characteristics/Differences of Sex Developmen
3 Beta-hydroxysteroid dehydrogenase type 2 Deficiency
Web Content Article
The adrenal glands, together with the testicles and ovaries, are organs responsible for the production of hormones. In some conditions, it may happen that the enzymes –i.e. the proteins necessary...
Infointersex Project:
Variations of Sex Characteristics/Differences of Sex Developmen
StAR Deficit (Steroidogenic Acute Regulatory protein)
Web Content Article
StAR (Steroidogenic Acute Regulatory protein) assists in transferring cholesterol across the mitochondrial membrane, initiating steroid production. Malfunctioning of this protein leads to...
Infointersex Project:
Variations of Sex Characteristics/Differences of Sex Developmen
Anorchia and Cryptorchidism
Web Content Article
Cryptorchidism occurs when one (unilateral cryptorchidism, 85% of cases) or both testicles (bilateral cryptorchidism, 15% of cases) fail to descend into the scrotal bursa. It is the most common...
Infointersex Project:
Variations of Sex Characteristics/Differences of Sex Developmen
Klinefelter Syndrome
Web Content Article
Klinefelter Syndrome (KS) is a Variation of Sex Characteristic (VSC)/Difference of Sex Development (DSD) caused by the presence of one or more extra X chromosomes in individuals with XY...
Infointersex Project:
Variations of Sex Characteristics/Differences of Sex Developmen
Hypospadias
Web Content Article
Hypospadias is a congenital anatomical variation of the penis, consisting in the incomplete development of the urethra (the duct that carries urine from the bladder through the penis to the...
Infointersex Project:
Variations of Sex Characteristics/Differences of Sex Developmen
5 Alpha-reductase Deficiency type 2
Web Content Article
During the development of a fetus with chromosomes 46,XY, the testes produce androgens (i.e., male hormones) that give genitals typically male characteristics. Specifically, the hormone involved is...
Infointersex Project:
Variations of Sex Characteristics/Differences of Sex Developmen
True Hermaphroditism
Web Content Article
Gonad is the generic term used to identify the organs responsible for the production of sperm and egg cells, i.e., the testicles and the ovaries, respectively. These organs also produce sex...
Infointersex Project:
Variations of Sex Characteristics/Differences of Sex Developmen
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