Chemical substances and health protection

TOPIC

Chemical substances and health protection

Chemical substances and health protection

The use of chemicals in modern society, in almost all production processes, makes the chemical sector one of the most important and globalized in the world economy. However, the essential contribution of these substances must be balanced with the identification of potential costs. These include the intensive use of water and energy as well as possible risks and negative impacts on the environment and human health. The diversity and potential gravity of these impacts make the management of chemicals an essential cross-cutting issue for sustainable development.

Consumers and users, if properly informed, can make a significant contribution to reducing risks, including through an informed choice of products and their responsible use.

The limitation of any damage to health and the environment can be guaranteed by the evaluation and management of substances throughout the entire life cycle, from production, to disposal, to reuse.

The Istituto Superiore di Sanità (ISS, the National Institute of Health in Italy) has a leading role in the Italian and European context in research, evaluation, management, control and regulation in the sector of chemicals and products and helps to protect human health by promoting innovation and competitiveness.

The ISS assesses the dangers and risks associated with substances and chemicals and is the national reference for the prevention and surveillance of dangerous exposures and intoxications, and for the national control plans and coordinates the network of national laboratories.

It also represents the technical-scientific interface of the European Chemicals Agency (ECHA), addressing emerging issues related to the health of the population.



Back Valutazione del pericolo

La valutazione del pericolo richiede la conoscenza delle proprietà intrinseche della sostanza capaci di arrecare un danno all’uomo o all’ambiente.

Per la valutazione dei pericoli fisici è necessario valutare le proprietà chimico fisiche delle sostanze.
Per i pericoli per la salute umana, è necessario valutare le possibili vie di ingresso della sostanza all’interno dell’organismo (via inalatoria, dermica e orale).
Per i pericoli per l’ambiente, è necessario valutare gli effetti ecotossicologici nei diversi comparti (acquatico, terrestre, atmosferico, ecc.).

Per la identificazione del pericolo vengono condotti test o raccolti dati disponibili

I test di tossicità per la salute umana possono essere condotti su:

  • animali da laboratorio (in vivo) ma solo a seguito di autorizzazione da parte di ECHA;
  • organi e tessuti prelevati da animali (ex vivo);
  • colture cellulari, microorganismi, frazioni subcellulari, enzimi purificati (in vitro);
  • oppure stimati attraverso modelli matematici e predittivi (in silico).

I test di ecotossicità per l’ambiente sono relativi a:

  • comparto (acquatico, terrestre o nessun comparto nel caso dei test tossicologici su mammiferi);
  • livello trofico (consumatore primario, consumatore secondario e produttore primario).

Gli studi tossicologici ed ecotossicologici devono essere condotti secondo le specifiche Linee Guida sui Test dell’OECD (Organisation for Economic Cooperation and Development – Test Guidelines) in centri di ricerca certificati per le Buone pratiche di laboratorio (GLP – Good Laboratory Practice).


NC for Chemicals

Sostanze chimiche

Dipartimenti/Centri/Servizi

Chemicals, cosmetics and consumer protection

Topics

Chemical substances and health protection Chemistry, health and sustainability