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03/34 - Progetto italiano sullepidemiologia della malattia di Alzheimer (IPREA) disegno dello studio e metodologia della fase trasversale. Emanuele Scafato, Claudia Gandin, Gino Farchi per il Gruppo IPREA 2003, iii, 106 p.
Italian PRoject on the Epidemiology of Alzheimer's disease (IPREA): study design and methodology of the cross sectional survey.
Emanuele Scafato, Claudia Gandin, Gino Farchi for IPREA Group
2003, iii, 106 p. Rapporti ISTISAN 03/34 (in Italian)
The design and the diagnostic procedures of the cross sectional survey of the multicentre community-based prospective study IPREA (Italian Project on the Epidemiology of Alzheimer's disease) are here described. The study is devoted to estimate the prevalence and the incidence of Alzheimer disease in the preclinical phase, to examine the natural history of cognitive decline without dementia in the Italian population, and to identify risk factors or health determinants related or associated with different health outcomes. Both cross-sectional and longitudinal phases will be performed in 4800 elderly subjects aged 65-84 years, selected from the registries of 12 Italian rural and urban municipalities. The study population will undergo different screening examinations, including a personal and an informant interview by an ad hoc structured questionnaire, a physical and neurological examination, laboratory tests, genetic markers and a neuropsychological battery. Furthermore, a neuroimaging will be assessed in a subgroup of subjects positive for cognitive impairment without dementia.
Key words: Alzheimer, Dementia, Preclinical diagnosis, Cross-sectional survey, Italy
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