Contact persons for Italy: Chiara Laura Battistelli, Cecilia Bossa e Olga Tcheremenskaia, Istituto Superiore di Sanità, Dipartimento di Ambiente e Salute
Integrated Approaches to Testing and Assessment (IATA) are structured approaches that integrate and weight information from different methodological approaches, such as (Q)SAR methodologies, in chemico/in vitro/ex vivo/in vivo testing, and omic technologies. IATA also have the potential to be mechanistically informed, by the use of Adverse Outcome Pathway (AOP) concept in their development.
IATA follow an iterative approach to answer a defined question in a specific regulatory context, taking into account the acceptable level of uncertainty associated with the decision context. There is a range of IATA - from more flexible, non-formalised judgement based approaches (e.g. grouping and read-across) to more structured, prescriptive, rule based approaches [e.g. Integrated Testing Strategy (ITS)].
The objective of the OECD IATA Case Studies Project is to increase experience on the use of IATA by developing case studies, which constitute examples of predictions that are fit regulatory use. The aim is to create common understanding of using novel methodologies and the generation of considerations/guidance stemming from the case studies.
The IATA Case Studies Project allows countries to share and explore the use of novel methodologies in IATA within a regulatory context.
For more information, please visit Integrated Approaches to Testing and Assessment (IATA) - OECD
