Volume 39, no. 2, March 2026. Origami: understanding epigenetics at all ages. Regulatory framework, responsibilities and roles in the remote control/monitoring of implantable cardiac devices. Nutritional intervention on inflammatory modulation in women and men with metabolic syndrome and type 2 diabetes

Abstracts:

Origami: understanding epigenetics at all ages
The human genome, as in an origami, follows folds, precise and fundamental instructions for building and operating an organism. Only 2% of the human genome encodes proteins, while the remaining 98% regulates gene activity. Epigenetics studies how the environment modulates the expression of genes through epigenetic modifications. These, like folds in DNA, make the genome dynamic and adaptable. We are not only what we inherit, but also what we experience. The enthusiasm of children to create origami gives hope for a future full of creativity, awareness, and collective attention for everyone's health.
 

Regulatory framework, responsibilities and roles in the remote control/monitoring of implantable cardiac devices
Remote monitoring of implantable cardiac devices enables the automatic transmission of clinical data, improving care and reducing visits and hospitalizations. Introduced in 2001, it is now an essential part of telemedicine. The European regulatory framework and related guidelines define the roles and responsibilities of all stakeholders. The General Data Protection Regulation (2016/679) protects personal data; the Medical Device Regulation (2017/745) ensures device safety, effectiveness, and proper intended use; and the AI Act (2024/1689) regulates high-risk artificial intelligence systems. The Heart Rhythm Society/European Heart Rhythm Association 2023 and European Society of Cardiology/European Heart Rhythm Association 2020 guidelines establish clinical, legal, and organizational standards, promoting safety, professional training, and structured data management.
 

Nutritional intervention on inflammatory modulation in women and men with metabolic syndrome and type 2 diabetes
The Center for Gender Specific Medicine of the Istituto Superiore di Sanità (National Institute of Health in Italy) is coordinating a study, in collaboration with the Fatebenefratelli Gemelli Isola Hospital, investigating the combined effect of a diet rich in flavonoids and fibers and pharmacological therapy with Glucagon-Like Peptide-1 analogues on inflammation, oxidative stress, and liver function in subjects with metabolic syndrome and type 2 diabetes, with particular emphasis on sex-based differences.