Istituto Superiore di Sanità
Interim guidance on Long-CoViD management principles. Version of July 1, 2021.
Graziano Onder, Marco Floridia, Marina Giuliano, Cinzia Lo Noce, Dorina Tiple, Luigi Bertinato, Rosanna Mariniello, Maria Grazia Laganà, Antonio Della Vecchia, Roberta Gianferro, Angela De Feo, Pierluigi Cosenza, Tiziana Di Corcia, Gianfranco Gensini, Ernesto Palummeri, Cristina Frabetti, Stefano Aliberti, Andrea Campana, Angelo Carfì, Francesco Landi, Alessandro Rossi, Antonio Cherubini, Antonio Uccelli, Emanuela Barisione, Luana Benedetti, Alessandro Bartoloni, Paolo Bonfanti, Marta Carlesimo, Giovanni Guaraldi, Jovana Milic, Salvatore Leonardi, Nicola Petrosillo, Paolo Tarsia
2021, iii, 27 p. Report ISS COVID-19 n. 15/2021
More than one year inside the CoViD-19 pandemic, it has now become clear that, for a relevant proportion of individuals affected by CoViD-19, significant clinical manifestations can persist after the first weeks of the acute symptomatic phase, with a heterogeneous complex of subacute and chronic symptoms that preclude a full return to the previous state of health. This persistence of symptoms, which can affect subjects of any age and with varying severity of the acute disease, has been recognized as a specific clinical entity, called Long-CoViD. Although the width of the symptomatology represents a challenge in terms of clinical definition and epidemiology, this condition has a significant clinical impact. The management of Long-CoViD requires special measures and funding and dedicated pathways of diagnosis and assistance, based on a multidisciplinary approach. This document summarizes the current framework of this new condition and provides general principles for its management, in line with the recommendations issued by the World Health Organization.
