general symptoms

Fatigue, muscular weakness, joint pain, and decline in quality of life

respiratory symptoms

Dyspnea, persistent cough, and decreased ability to expand the rib cage

cardiovascular symptoms

Tightness and chest pain, tachycardia and palpitations at the slightest exertion, arrhythmias, and change in blood pressure

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The Istituto Superiore di Sanità is the lead partner of the project "Analysis and strategies of response to the long-term effects of CoViD-19 infection (Long-CoViD) " coordinated by Graziano Onder, Director of the Cardiovascular, Endocrine-Metabolic diseases and Aging Department of the ISS.


The term Long-CoViD is used to describe a wide range of physical and mental health consequences that are still present four or more weeks after SARS-CoV-2 infection, despite the negativization of the diagnostic test for CoViD-19. The most frequent symptoms are fatigue and "mental fog", i.e. memory problems and difficulty concentrating, loss of smell and taste, and respiratory and cardiovascular symptoms.


The general objective of monitoring the long-term effects of the CoViD-19 pandemic is split in 5 specific goals:

1. Defining the dimensions of the Long-CoViD condition

2. Mapping number, characteristics and distribution of Italian Long-CoViD centers

3. Defining the best practices in the field of Long-CoViD

4. Setting up a Long-CoViD surveillance system

5. Structuring of the national network


"Long-CoViD: ready to face the present and the future impact of the pandemic?".

Throughout the project, regular webinars will be organized to update about the Long-CoViD condition. In this section, you will find links to online events and programs. Check it out now