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EFSA: assessment of endocrine disrupting properties of 41 pesticides

Regulation (EC) No 1107/2009 introduced new criteria for the approval of pesticide active substances, including the exclusion of substances with endocrine disrupting properties. The Regulation calls for specific scientific criteria for the determination of such properties; while the adoption of robust criteria is still pending, interim criteria’ have been used, including the detection of toxic effects on the endocrine organs. Since 2014, EFSA has published 15 Conclusions on new active substances and 26 on applications for renewal that explicitly summarise the assessment of potential endocrine effects. For 24 active substances, including 3 microbial pesticide active substances, the available information has not led to the detection of specific concerns, however in the case of two of...

Published 10-05-2015 in Emerging aspects , last update 10-05-2015 More...



This section collects scientific references on possible approaches aimed to mitigate the exposure and/or hazard from endocrine disrupters and other contaminants concerning human health.

  • Alija AJ, Bresgen N, Bojaxhi E, Vogl C, Siems W, Eckl PM. Cytotoxicity of beta-carotene cleavage products and its prevention by antioxidants. Acta Biochim Pol. 2010;57(2):217-21.
  • Andersson M, Karumbunathan V, Zimmermann MB. Global Iodine Status in 2011 and Trends over the Past Decade. J Nutr. 2012 Apr;142(4):744-50.
  • Atwood KC, Woeckner E, Baratz RS, Sampson WI. Why the NIH Trial to Assess Chelation Therapy (TACT) should be abandoned. Medscape J Med. 2008 May 13;10(5):115.
  • Bradman A, Quirós-Alcalá L, Castorina R, Schall RA, Camacho J, Holland NT, Barr DB,...

    Published 10-04-2010 in Risk mitigation , last update 10-01-2015 More...


Literature concerning ED and feeds

  • Battisti S, Caminiti A, Ciotoli G, Panetta V, Rombolà P, Sala M, Ubaldi A, Scaramozzino P. A spatial, statistical approach to map the risk of milk contamination by beta;-hexachlorocyclohexane in dairy farms. Geospat Health. 2013 Nov;8(1):77-86.
  • Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO). Executive summary of the report on Joint FAO/WHO expert meeting on hazards associated with animal feed. (12-15 May 201, FAO, Rome).
  • Flachowsky G, Franke K, Meyer U, Leiterer M, Schöne F. Influencing factors on iodine content of cow milk. Eur J Nutr. 2014 Mar;53(2):351-65.
  • Frazzoli C, Mantovani A. (2010) Toxicants Exposures as Novel...

    Published 06-22-2009 in ED and feeds , last update 08-27-2015 More...


Endocrine active substances in feeds

Endocrine active substances in feeds may represent either a direct risk for farm animals, an important exposure factor for consumers, particularly for vulnerable groups such as children as well an environmental issue associated with contaminants present in animal excreta. Therefore, this is an important issue in the novel "One Health" framework, which integrates environmental quality, animal health, food safety and human health.
Within EFSA this issue is considered by two panels:
- Panel on contaminants in the food chain (CONTAM) as regards undesirable substances, mainly of environmental origin, such as persistent contaminants and mycotoxins.
- Panel on additives and products or substances used in animal feed (FEEDAP)as regards substances intentionally added to feeds to...

Published 12-04-2006 in ED and feeds , last update 08-27-2015 More...


Food Chains and Ecosystems

This section collects scientific references on possible approaches aimed to mitigate the exposure and/or hazard from endocrine disrupters and other contaminants in food chains and the environment .

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