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EFSA opinion on Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones

The EFSA ANS Panel (Food Additives and Nutrient Sources added to food) was asked to deliver a scientific opinion on the possible association between the intake of isoflavones from food supplements and harmful effects on mammary gland, uterus and thyroid in peri- and post-menopausal women. Isoflavones are naturally occurring substances which can be found in, among other sources, soy, red clover and kudzu root. The main isoflavones are genistein, daidzein, glycitein, formononetin, biochanin A and puerarin. Their chemical structures are related to 17β-oestradiol and they possess oestrogenic properties.
Furthermore, isoflavones may interact with the synthesis of thyroid hormone. Food supplements targeted at peri- and post-menopausal women typically provide a daily dose of...

Published 10-22-2015 in Emerging aspects , last update 10-22-2015 More...


The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals

This Executive Summary to the Endocrine Society's second Scientific Statement on environmental endocrine-disrupting chemicals (EDCs) provides a synthesis of the key points of the complete statement. The full Scientific Statement represents a comprehensive review of the literature on seven topics for which there is strong mechanistic, experimental, animal, and epidemiological evidence for endocrine disruption, namely: obesity and diabetes, female reproduction, male reproduction, hormone-sensitive cancers in females, prostate cancer, thyroid, and neurodevelopment and neuroendocrine systems.
EDCs such as bisphenol A, phthalates, pesticides, persistent organic pollutants such as polychlorinated biphenyls, polybrominated diethyl ethers, and dioxins were emphasized because these chemicals...

Published 10-22-2015 in Emerging aspects , last update 10-22-2015 More...



EFSA: assessment of endocrine disrupting properties of 41 pesticides

Regulation (EC) No 1107/2009 introduced new criteria for the approval of pesticide active substances, including the exclusion of substances with endocrine disrupting properties. The Regulation calls for specific scientific criteria for the determination of such properties; while the adoption of robust criteria is still pending, interim criteria’ have been used, including the detection of toxic effects on the endocrine organs. Since 2014, EFSA has published 15 Conclusions on new active substances and 26 on applications for renewal that explicitly summarise the assessment of potential endocrine effects. For 24 active substances, including 3 microbial pesticide active substances, the available information has not led to the detection of specific concerns, however in the case of two of...

Published 10-05-2015 in Emerging aspects , last update 10-05-2015 More...



This section collects scientific references on possible approaches aimed to mitigate the exposure and/or hazard from endocrine disrupters and other contaminants concerning human health.

  • Alija AJ, Bresgen N, Bojaxhi E, Vogl C, Siems W, Eckl PM. Cytotoxicity of beta-carotene cleavage products and its prevention by antioxidants. Acta Biochim Pol. 2010;57(2):217-21.
  • Andersson M, Karumbunathan V, Zimmermann MB. Global Iodine Status in 2011 and Trends over the Past Decade. J Nutr. 2012 Apr;142(4):744-50.
  • Atwood KC, Woeckner E, Baratz RS, Sampson WI. Why the NIH Trial to Assess Chelation Therapy (TACT) should be abandoned. Medscape J Med. 2008 May 13;10(5):115.
  • Bradman A, Quirós-Alcalá L, Castorina R, Schall RA, Camacho J, Holland NT, Barr DB,...

    Published 10-04-2010 in Risk mitigation , last update 10-01-2015 More...


Literature concerning ED and feeds

  • Battisti S, Caminiti A, Ciotoli G, Panetta V, Rombolà P, Sala M, Ubaldi A, Scaramozzino P. A spatial, statistical approach to map the risk of milk contamination by beta;-hexachlorocyclohexane in dairy farms. Geospat Health. 2013 Nov;8(1):77-86.
  • Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO). Executive summary of the report on Joint FAO/WHO expert meeting on hazards associated with animal feed. (12-15 May 201, FAO, Rome).
  • Flachowsky G, Franke K, Meyer U, Leiterer M, Schöne F. Influencing factors on iodine content of cow milk. Eur J Nutr. 2014 Mar;53(2):351-65.
  • Frazzoli C, Mantovani A. (2010) Toxicants Exposures as Novel...

    Published 06-22-2009 in ED and feeds , last update 08-27-2015 More...


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