The EFSA ANS Panel (Food Additives and Nutrient Sources added to food) was asked to deliver a scientific opinion on the possible association between the intake of isoflavones from food supplements and harmful effects on mammary gland, uterus and thyroid in peri- and post-menopausal women. Isoflavones are naturally occurring substances which can be found in, among other sources, soy, red clover and kudzu root. The main isoflavones are genistein, daidzein, glycitein, formononetin, biochanin A and puerarin. Their chemical structures are related to 17β-oestradiol and they possess oestrogenic properties.
Furthermore, isoflavones may interact with the synthesis of thyroid hormone. Food supplements targeted at peri- and post-menopausal women typically provide a daily dose of...
This Executive Summary to the Endocrine Society's second Scientific Statement on environmental endocrine-disrupting chemicals (EDCs) provides a synthesis of the key points of the complete statement. The full Scientific Statement represents a comprehensive review of the literature on seven topics for which there is strong mechanistic, experimental, animal, and epidemiological evidence for endocrine disruption, namely: obesity and diabetes, female reproduction, male reproduction, hormone-sensitive cancers in females, prostate cancer, thyroid, and neurodevelopment and neuroendocrine systems.
EDCs such as bisphenol A, phthalates, pesticides, persistent organic pollutants such as polychlorinated biphenyls, polybrominated diethyl ethers, and dioxins were emphasized because these chemicals...
Regulation (EC) No 1107/2009 introduced new criteria for the approval of pesticide active substances, including the exclusion of substances with endocrine disrupting properties. The Regulation calls for specific scientific criteria for the determination of such properties; while the adoption of robust criteria is still pending, interim criteria’ have been used, including the detection of toxic effects on the endocrine organs. Since 2014, EFSA has published 15 Conclusions on new active substances and 26 on applications for renewal that explicitly summarise the assessment of potential endocrine effects. For 24 active substances, including 3 microbial pesticide active substances, the available information has not led to the detection of specific concerns, however in the case of two of...
This section collects scientific references on possible approaches aimed to mitigate the exposure and/or hazard from endocrine disrupters and other contaminants concerning human health.
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